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Comparative Study of Autologous Blood Injection Versus Diluted Epinephrine in Treating Actively Bleeding Gastroduodenal Ulcers

Information source: Zagazig University
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Blood, Injection, Injury Type Phobia; Gastrointestinal Ulcer Haemorrhage; Adverse Reaction to Epinephrine

Intervention: Epinephrine (Drug); Blood (Biological)

Phase: N/A

Status: Completed

Sponsored by: Zagazig University

Official(s) and/or principal investigator(s):
Mohamed H Emara, MD, Principal Investigator, Affiliation: Tropical Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, 44519, Egypt

Summary

Endoscopic injection of autologous blood can control bleeding from gastroduodenal ulcers.

Clinical Details

Official title: Endoscopic Injection of Autologous Blood Versus Diluted Epinephrine for Control of Actively Bleeding Gastroduodenal Ulcers

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: hemostasis from the ulcer after injection and/or stoppage of haematemesis and melena one day after the procedure.

Secondary outcome: development of re-bleeding after 24 hours after the procedure (occurrence of hematemesis or melena or drop of hemoglobin level >2gm/dl).

Detailed description: To test the hypothesis that endoscopic injection of autologous blood is superior to endoscopic injection of diluted epinephrine in controlling bleeding from gastroduodenal ulcers.

Eligibility

Minimum age: 16 Years. Maximum age: 60 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- all adult patients with gastroduodenal ulcer

Exclusion Criteria:

- Patients with non ulcer bleeding.

- Patients with malignancy.

- Patients with bleeding disorders or under coagulation therapy.

- Patients with known allergy to epinephrine.

Locations and Contacts

Zagazig University Hospitals, Zagazig, Sharkia 44519, Egypt
Additional Information

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Starting date: March 2012
Last updated: September 24, 2013

Page last updated: August 20, 2015

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