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Dose, Effects and Characteristics of Pilocarpine

Information source: Wills Eye
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Open-Angle Glaucoma

Intervention: Pilocarpine Concentration (Drug); Pilocarpine Frequency (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: Wills Eye

Official(s) and/or principal investigator(s):
George L Spaeth, MD, Principal Investigator, Affiliation: Wills Eye Glaucoma Service


The purpose of this investigation, in which pilocarpine was given in repeated doses, was to

evaluate: Part I - the effects of different concentrations of pilocarpine hydrochloride on

intraocular pressure. Part II - the effects on intraocular pressure of glaucomatous patients

to pilocarpine 2% when given once, twice and four daily. In addition, we studied various attributes of the eye which may serve as indicators of responsiveness of individual patients to pilocarpine.

Clinical Details

Official title: Dose, Effects and Characteristics of Pilocarpine

Study design: Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Intraocular Pressure


Minimum age: 18 Years. Maximum age: 90 Years. Gender(s): Both.


Inclusion Criteria:

- Primary open-angle glaucoma

- Primary open-angle glaucoma suspect

Locations and Contacts

Wills Eye Glaucoma Service, Philadelphia, Pennsylvania 19107, United States
Additional Information

Starting date: August 1978
Last updated: December 8, 2008

Page last updated: August 23, 2015

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