Evaluation of the Minimum Effective Concentration of Bupivacaine (EC50) in Femoral Block for Analgesia by Ultrasound After Knee Surgery
Information source: Federal University of São Paulo
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Knee Surgery; Postoperative Pain
Intervention: Bupivacaine (Drug)
Phase: Phase 4
Status: Recruiting
Sponsored by: Ed Carlos Rey Moura Official(s) and/or principal investigator(s):
Ed Carlos Moura, research, Principal Investigator, Affiliation: Federal University of São Paulo
Overall contact:
Ed Carlos Moura, research, Phone: 559884046958, Email: edcrmoura@yahoo.com.br
Summary
The purpose of the study is to determine the minimum effective concentration of bupivacaine
(EC50) in femoral block for analgesia by ultrasound after knee surgery.
Clinical Details
Official title: Evaluation of the Minimum Effective Concentration of Bupivacaine (EC50) in Femoral Block for Analgesia by Ultrasound After Knee Surgery
Study design: Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
Primary outcome: Pain Scores on the Visual Analog Scale
Detailed description:
45 patients classified as ASA P1 or P2 aged between 18 and 65 candidates for elective knee
operation via arthroscopy were included in the study. All patients received femoral nerve
block guided by ultrasound with bupivacaine, 22 ml. The first patient at a concentration of
0. 25%. The other patients with higher or lower concentrations if the first patient has pain>
3 or <3 on visual analogic scale respectively after awakening of surgical anesthesia. For
surgical anesthesia each patient will undergo general anesthesia. At the end of the surgical
procedure and anesthetic awakening patients will be evaluated for analgesia by verbal
numeric scale. The modified Dixon method was used to find the EC50 and EC95 of bupivacaine
for analgesia of femoral nerve block guided by ultrasound. Concentration still correlated
with motor block and side effects.
Eligibility
Minimum age: 18 Years.
Maximum age: 65 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- patients to undergo knee surgery
Exclusion Criteria:
- patients with coagulopathy
- pregnant
- infection at the puncture site
- chronic pain
Locations and Contacts
Ed Carlos Moura, research, Phone: 559884046958, Email: edcrmoura@yahoo.com.br
Universidade Federal de São Paulo, São Paulo, SP 04023-061, Brazil; Recruiting
Ed Carlos Moura, research, Phone: 559884046958, Email: edcrmoura@yahoo.com.br
Additional Information
Starting date: July 2013
Last updated: April 24, 2014
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