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Evaluation of the Minimum Effective Concentration of Bupivacaine (EC50) in Femoral Block for Analgesia by Ultrasound After Knee Surgery

Information source: Federal University of So Paulo
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Knee Surgery; Postoperative Pain

Intervention: Bupivacaine (Drug)

Phase: Phase 4

Status: Recruiting

Sponsored by: Ed Carlos Rey Moura

Official(s) and/or principal investigator(s):
Ed Carlos Moura, research, Principal Investigator, Affiliation: Federal University of São Paulo

Overall contact:
Ed Carlos Moura, research, Phone: 559884046958, Email: edcrmoura@yahoo.com.br

Summary

The purpose of the study is to determine the minimum effective concentration of bupivacaine (EC50) in femoral block for analgesia by ultrasound after knee surgery.

Clinical Details

Official title: Evaluation of the Minimum Effective Concentration of Bupivacaine (EC50) in Femoral Block for Analgesia by Ultrasound After Knee Surgery

Study design: Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment

Primary outcome: Pain Scores on the Visual Analog Scale

Detailed description: 45 patients classified as ASA P1 or P2 aged between 18 and 65 candidates for elective knee operation via arthroscopy were included in the study. All patients received femoral nerve block guided by ultrasound with bupivacaine, 22 ml. The first patient at a concentration of 0. 25%. The other patients with higher or lower concentrations if the first patient has pain> 3 or <3 on visual analogic scale respectively after awakening of surgical anesthesia. For surgical anesthesia each patient will undergo general anesthesia. At the end of the surgical procedure and anesthetic awakening patients will be evaluated for analgesia by verbal numeric scale. The modified Dixon method was used to find the EC50 and EC95 of bupivacaine for analgesia of femoral nerve block guided by ultrasound. Concentration still correlated with motor block and side effects.

Eligibility

Minimum age: 18 Years. Maximum age: 65 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- patients to undergo knee surgery

Exclusion Criteria:

- patients with coagulopathy

- pregnant

- infection at the puncture site

- chronic pain

Locations and Contacts

Ed Carlos Moura, research, Phone: 559884046958, Email: edcrmoura@yahoo.com.br

Universidade Federal de São Paulo, São Paulo, SP 04023-061, Brazil; Recruiting
Ed Carlos Moura, research, Phone: 559884046958, Email: edcrmoura@yahoo.com.br
Additional Information

Starting date: July 2013
Last updated: April 24, 2014

Page last updated: August 23, 2015

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