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Antitussive Effect of Single-dose Dexmedetomidine With Low-dose Remifentanil Infusion

Information source: Yonsei University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Thyroidectomy

Intervention: Dexmedetomidine + Remifentanil-low dose (Drug); Remifentanil-high dose (Drug)

Phase: Phase 4

Status: Recruiting

Sponsored by: Yonsei University

Official(s) and/or principal investigator(s):
Jeong Soo Lee, Principal Investigator, Affiliation: Yonsei University

Overall contact:
Jeong Soo Lee, Phone: 82-2-2019-6092, Email: ration99@yuhs.ac


After thyroid surgery, the incidence and severity of coughing is important because it may cause serious complications, such as bleeding in the surgical field, laryngospasm, and cardiovascular disturbance. Several studies have shown that the single-dose of dexmedetomidine is effective for reducing cough and agitation during emergence from general anesthesia. To test the hypothesis that single-dose of dexmedetomidine combined with a low-dose remifentanil infusion during emergence from general anaesthesia could reduce coughing as good as high-dose remifentanil infusion, we will evaluate the efficacy on cough suppression and reduction of side effect of remifentanil using non-inferiority trial.

Clinical Details

Official title: Antitussive Effect of Single-dose Dexmedetomidine With Low-dose Remifentanil Infusion During Emergence in Adults After Thyroidectomy: Comparison With High-dose Remifentanil Infusion Alone

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Primary outcome: Incidence of coughing during emergence from general anesthesia

Secondary outcome: side effect of remifentanil


Minimum age: 20 Years. Maximum age: 65 Years. Gender(s): Both.


Inclusion Criteria:

- Thyroid disease undergoing thyroidectomy

- age 20-65

- Amerian society of anesthesgiologist class 1 or 2

Exclusion Criteria:

- chronic cough

- difficult intubation

- liver disease

- uncontrolled hypertension

Locations and Contacts

Jeong Soo Lee, Phone: 82-2-2019-6092, Email: ration99@yuhs.ac

Gangnam severance hospital, Seoul 135-720, Korea, Republic of; Recruiting
Additional Information

Starting date: February 2014
Last updated: June 25, 2015

Page last updated: August 23, 2015

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