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The Effect of Alfa-Adrenergic Receptor Blockade on Insulin-Stimulated Forearm Glucose Uptake and Metabolism in Chronic Heart Failure

Information source: Radboud University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Heart Failure, Congestive

Intervention: phentolamine (Drug)

Phase: N/A

Status: Recruiting

Sponsored by: Radboud University

Official(s) and/or principal investigator(s):
Cees J Tack, MD, PhD, Principal Investigator, Affiliation: Radboud University

Overall contact:
Marc E.R. Gomes, MD, Phone: +31-24-3614533/3616550, Email: m.gomes@cardio.umcn.nl

Summary

The activity of the sympathetic nervous system seems to influence the uptake (and handling) of glucose by the skeletal muscle of the forearm. Conditions in which sympathetic activity is increased seem to inhibit/reduce forearm glucose uptake. Inversely a decrease in sympathetic activity seems to increase glucose uptake. This study analyzes the effect of alfa-adrenergic receptor blockade (counteracting sympathetic influence) on insulin-stimulated forearm glucose uptake in patients with increased sympathetic activity (patients with chronic heart failure).

Clinical Details

Official title: The Effect of a-Adrenergic Receptor Blockade on Insulin-Stimulated Forearm Glucose Uptake and Metabolism in Chronic Heart Failure

Study design: Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label

Primary outcome: change in glucose uptake

Eligibility

Minimum age: 18 Years. Maximum age: 75 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Heart failure of at least New York Heart Association (NYHA) class II

- Left ventricular ejection fraction (LVEF) <= 40%

- Age 18-75 years

Exclusion Criteria:

- Alfa-blockers, or beta-blockers with alfa-blocking activity (carvedilol)

- Tricyclic antidepressants

- Warfarin derivatives (acetylic salicylic acid and clopidogrel are allowed)

- Hospitalisation in 6 weeks prior to the study

- Any change in medication in 6 weeks prior to the study

- Unstable angina

- Orthopnoea

- Known chronic disease of the autonomic nervous system

- Diabetes mellitus

- Oedema of the lower extremities, complicating the insertion of a venous catheter in

a vein on the foot

Locations and Contacts

Marc E.R. Gomes, MD, Phone: +31-24-3614533/3616550, Email: m.gomes@cardio.umcn.nl

Radboud University Nijmegen Medical Centre, Nijmegen 6500 HB, Netherlands; Recruiting
Marc ER Gomes, MD, Phone: 31-24-3614533/3616550, Email: m.gomes@cardio.umcn.nl
Marc ER Gomes, MD, Sub-Investigator
Alexandra H Mulder, MD, Sub-Investigator
Freek WA Verheugt, MD, PhD, Sub-Investigator
Paul Smits, MD, PhD, Sub-Investigator
Cees J Tack, MD, PhD, Principal Investigator
Louise Bellersen, MD, Sub-Investigator
Additional Information

Starting date: August 2005
Last updated: August 30, 2007

Page last updated: August 23, 2015

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