Vasopressin and Epinephrine Versus Epinephrine Alone in Cardiac Arrest
Information source: Hospices Civils de Lyon
ClinicalTrials.gov processed this data on August 20, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Cardiac Arrest
Intervention: epinephrine (1 mg/1 mL) (Drug); arginine-vasopressin (40 UI/2 mL) (Drug)
Phase: Phase 4
Status: Completed
Sponsored by: Hospices Civils de Lyon Official(s) and/or principal investigator(s): Pierre-Yves GUEUGNIAUD, MD, Principal Investigator, Affiliation: Hospices Civils de Lyon
Summary
Recent studies have suggested that arginine-vasopressin could be more effective in the
treatment of cardiac arrests. The last published study did not outline obvious improvements
in the prognosis of all cardiac arrests but pointed out a possible increased survival rate
when arginine-vasopressin is associated with epinephrine. The aim of this study is to
compare the efficacy of two successive injections of epinephrine (1 mg) with two successive
injections of epinephrine associated with arginine-vasopressin (40 UI) in out-of-hospital
cardiac arrests occurring in adult patients. The primary endpoint is the survival rate at
hospital admission. The inclusion period lasts 18 months and 2416 patients are planned to be
enrolled.
Clinical Details
Official title: Comparison of Epinephrine Associated With Vasopressin vs Epinephrine Alone in the Treatment of Out-of-Hospital Cardiac Arrests
Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
Primary outcome: Survival at hospital admission
Secondary outcome: ROSC (Return of spontaneous circulation) Survival at : H24, Day 28, hospital discharge and one year Neurological status at H24 and hospital discharge.
Eligibility
Minimum age: 18 Years.
Maximum age: 85 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Out-of-hospital medical cardiac arrest in adult patients.
Exclusion Criteria:
- Traumatic cardiac arrest
- Pregnancy
- Patients younger than 18 years old or older than 85 years old
Locations and Contacts
Centre Hospitalier Lyon Sud, Pierre BĂ©nite 69495, France
Additional Information
Starting date: May 2004
Last updated: October 16, 2007
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