The randomized patients with acute heart failure will be stratified based on the presence or
absence of a Swan-Ganz catheter and assigned to receive either tezosentan 5 mg/h for the
first 30 minutes and 1 mg/h thereafter or matching placebo in a 1: 1 manner. The duration of
the treatment is 24 hours up to 72 hours. The duration of the follow-up period is 30 days
after treatment initiation for death, re-hospitalizations and SAEs followed by a follow-up
period of 5 months for vital status.
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
AKH University of Vienna, Abt. Medizinische Kardiologie, Vienna, Austria
Roskilde Amt Sygehus, Roskilde, Denmark
Hopital Ambroise Pare, Service de Cardiologie, Boulogne, France
Heart Failure clinic C.H. Dubos, Pontoise, France
Hopitaux Universitaires de Strasbourg, Hopital Hautepierre, Strasbourg, France
CHU Rangueil, Cardiologie A, Toulouse, France
Medizinische Klinik I, Universitatsklinikum Aachen, Aachen, Germany
Campus Virchow-Klinikum, Medizinishe Klinik mit Schwerpunkt Kardiologie, Berlin, Germany
Georg-August-Universitat Gottingen, Zentrum fur Innere Med, Gottingen, Germany
Dept. of Cardiology, University of Athens, Alexandra Hospital, Athens, Greece
Barzilai Hospital, Ashkelon, Israel
Carmel Medical Center, Haifa, Israel
Wolfson Medical Center, Holon, Israel
Hadassah Hospital, Jerusalem, Israel
Nazareth Hospital EMMS, Nazareth, Israel
Assaf-Harofeh Medical Center, Zerifin, Israel
Klinika Kardiologii i Chorob Wewnetrznych, Samodzielny Publiczny Szpital, Bydgoszcz, Poland
Klinika Chorob Serca, Akademia Medyczna w Gdansku, Gdansk, Poland
I Klinika Kardiolgii, Collegium Medicum UJ, Krakow, Poland
Institute of Cardiology College, College of Medicine of Jagellonian University, Krakow, Poland
Kategra I Klinika Kardiolgii AM, Wroclaw, Poland
Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland
Cardio Centro Ticino, Servizio Cardiovasculare, Lugano, Switzerland
University Hospital Zurich, Zurich, Switzerland
Glasgow Royal Infirmary, Glasgow, United Kingdom
Hull Royal Infirmary, Kingston Upon Hull, United Kingdom
Scunthorpe General Hospital, Scunthorpe `, United Kingdom
University of Alabama-Birmingham, Birmingham, Alabama, United States
Advanced Heart Failure and Transplant Service, Palo Alto VA Health Care System, Cardiology Section, Palo Alto, California, United States
Denver VAMC, Denver, Colorado, United States
The Heart Hospital at Alledgheny General, Division of Cardiology, Pittsburgh, Pennsylvania, United States
Veterans Affairs Medical Center, Houston, Texas, United States
Tyler Cardiovascular Consultants, Tyler, Texas, United States
Danville Medical Center, Danville, Virginia, United States
Medical Associates, Bellebue, Bellevue, Washington, United States