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Carbachols Headache-inducing Effect and Changes in Cerebral Blood Flow in Migraine Patients

Information source: Danish Headache Center
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Headache

Intervention: Carbachol (Drug)

Phase: N/A

Status: Completed

Sponsored by: Danish Headache Center

Official(s) and/or principal investigator(s):
Henrik Schytz, MD, Principal Investigator, Affiliation: Danish Headache Center


The purpose of this study is to test if carbachol infusion induces headache in migraine subjects as well as intra- and extra-cerebral vasodilatation.

Clinical Details

Official title: Experimental Study That Investigates the Effect of an Acetylcholine Analogue in Terms of Headache and Changes in Intra- and Extra-cerebral Vessels During and After Infusion of Carbachol

Study design: Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science

Primary outcome: Headache response after Carbachol infusion

Detailed description: To test if infusion of Carbachol induces headache in 12 migraine subjects as well as intra- and extra-cerebral vasodilatation in a double-blinded study


Minimum age: 18 Years. Maximum age: 50 Years. Gender(s): Both.


Inclusion Criteria:

- Migraine without aura

- Weight 50-100 kg

Exclusion Criteria:

- Other significant diseases

- Migraine 5 days prior to experiment

Locations and Contacts

Danish Headache Center, Glostrup 2600, Denmark
Additional Information

Starting date: August 2007
Last updated: July 31, 2009

Page last updated: August 23, 2015

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