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Docetaxel and Prednisone With or Without Vaccine Therapy in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer

Information source: National Cancer Institute (NCI)
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Hormone-Resistant Prostate Cancer; Prostate Adenocarcinoma; Recurrent Prostate Carcinoma; Stage IV Prostate Cancer

Intervention: Docetaxel (Drug); Laboratory Biomarker Analysis (Other); Prednisone (Drug); Recombinant Fowlpox-PSA(L155)/TRICOM Vaccine (Biological); Rilimogene-galvacirepvec (Biological)

Phase: Phase 2

Status: Active, not recruiting

Sponsored by: National Cancer Institute (NCI)

Official(s) and/or principal investigator(s):
Douglas McNeel, Principal Investigator, Affiliation: ECOG-ACRIN Cancer Research Group


This randomized phase II trial studies how well docetaxel and prednisone with or without vaccine therapy works in treating patients with hormone-resistant prostate cancer that has spread to other parts of the body. Drugs used in chemotherapy, such as docetaxel and prednisone, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Vaccines made from an antigen may help the body build an effective immune response to kill tumor cells. It is not yet known whether docetaxel and prednisone are more effective with or without vaccine therapy in treating prostate cancer.

Clinical Details

Official title: Randomized Phase II Trial of Docetaxel With or Without PSA-TRICOM Vaccine in Patients With Castrate-Resistant Metastatic Prostate Cancer

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Overall Survival

Detailed description: PRIMARY OBJECTIVES: I. To evaluate the overall survival in patients treated with PSA-TRICOM (fowlpox-PSA-TRICOM vaccine and rilimogene-galvacirepvec) and docetaxel chemotherapy versus docetaxel chemotherapy only. SECONDARY OBJECTIVES: I. To evaluate the time to radiographic progression after beginning docetaxel chemotherapy in patients previously treated with PSA-TRICOM vaccine versus those not treated with this vaccine. II. To compare objective responses (according to Response Evaluation Criteria in Solid Tumors [RECIST]) between the two treatment groups in those patients with measurable disease. III. To evaluate prostate-specific antigen (PSA) response rates (decline >= 50%) in patients treated with PSA-TRICOM and docetaxel chemotherapy versus docetaxel chemotherapy only. IV. To evaluate immune responses elicited in patients treated before and after docetaxel chemotherapy. V. To evaluate the association between development of prostate antigen-specific immune responses and time to progression and overall survival. VI. To evaluate the association of predicted survival (by Halabi nomogram) with actual survival in patients treated with PSA-TRICOM vaccine versus those not treated with this vaccine. OUTLINE: Patients are randomized to 1 of 2 treatment arms. ARM A (vaccine and chemotherapy): Patients receive rilimogene-galvacirepvec subcutaneously (SC) on day 1 of course 1 and fowlpox-PSA-TRICOM vaccine SC on days 15, 29, 43, and 57 of course 1. Beginning on day 85 (day 1 of course 2), patients receive docetaxel intravenously (IV) over 1 hour on day 1 and prednisone orally (PO) twice daily (BID) on days 1-21. Treatment with docetaxel and prednisone repeats every 21 days for up to 12 courses in the absence of disease progression or unacceptable toxicity. ARM B (chemotherapy): Patients receive docetaxel IV over 1 hour on day 1 and prednisone PO BID on days 1-21. Treatment repeats every 21 days for up to 12 courses in the absence of disease progression or unacceptable toxicity. After completion of study therapy, patients are followed up every 3 months for 2 years and then every 6 months for 3 years.


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Male.


Inclusion Criteria:

- Patient must have histologically confirmed diagnosis of prostate cancer

(adenocarcinoma of the prostate)

- Patient must have metastatic disease as evidenced by the presence of soft tissue

and/or bone metastases on imaging studies (computed tomography [CT] of abdomen/pelvis, bone scintigraphy)

- Patient must have castrate-resistant disease, defined as follows:

- Patient must have received standard of care androgen deprivation treatment (ADT)

before trial entry (surgical castration versus gonadotropin-releasing hormone [GnRH] analogue or antagonist treatment); subjects receiving GnRH analogue or antagonist must continue this treatment throughout the time on this study

- Patient must have been treated previously with a nonsteroidal antiandrogen, with

evidence of subsequent disease progression; subjects must be off use of anti-androgen for at least 4 weeks (for flutamide) or 6 weeks (for bicalutamide or nilutamide) prior to randomization; subjects who demonstrate an anti-androgen withdrawal response, defined as a >= 25% decline in PSA within 4-6 week of stopping a nonsteroidal antiandrogen are not eligible until the PSA rises above the nadir observed after antiandrogen withdrawal

- Patient must have castration levels of testosterone (< 50 ng/dL) within 4 weeks

prior to randomization

- Patient must have progressive disease while receiving ADT as defined by any one of

the following as per the Prostate Cancer Clinical Trials Working Group 2 (PCWG2) criteria:

- PSA: at least two consecutive rises in serum PSA, obtained at a minimum of

1-week intervals, and each value >= 2. 0 ng/mL

- Measurable disease: >= 50% increase in the sum of the cross products of all

measurable lesions or the development of new measurable lesions by RECIST criteria version 1. 1; the greatest diameter of a target lesion must be at least 1. 0 cm by CT scan (1. 5 cm in shortest axis for lymph nodes)

- Non-measurable (bone) disease: the appearance of two or more new areas of uptake

on bone scan consistent with metastatic disease compared to previous imaging during castration therapy; the increased uptake of pre-existing lesions on bone scan will not be taken to constitute progression, and ambiguous results must be confirmed by other imaging modalities (e. g. X-ray, CT or magnetic resonance imaging [MRI])

- Patient must not have poor prognosis features suggested by the following required


- Presence of visceral (non-lymph node, non-bone) metastases

- Poor performance status (Eastern Cooperative Oncology Group [ECOG] performance

status [PS] of 2 or greater)

- Alkaline phosphatase (IU/L) > 2 x institutional upper limit of normal

- Lactate dehydrogenase (LDH) (U/L) > 2 x institutional upper limit of normal

- Patient must have an ECOG performance status of 0 or 1

- White blood cell (WBC) count >= 2000/mm^3

- Absolute neutrophil count (ANC) >= 1500/mm^3

- Platelet count >= 100,000/mm^3

- Creatinine =< 2. 0 mg/dL

- Aspartate aminotransferase (AST), alanine aminotransferase (ALT) =< 1. 5 x

institutional upper limit of normal (ULN)

- Total bilirubin < institutional upper limit of normal (ULN)

- Patient must have completed any prior treatments (apart from androgen deprivation as

previously described) >= 4 weeks prior to randomization and have recovered (to < grade 2) from any acute toxicities attributed to this prior treatment

- Patient must agree to use an accepted and effective method of contraception prior to

study entry and for the duration of study participation (or at least 4 months after the last vaccination in subjects receiving vaccine series); if patient impregnates a woman while participating in this study, he should inform his treating physician immediately

- Patient must not be receiving any other investigational agents or be receiving

concurrent anticancer therapy other than ADT

- Patient must not have been treated with a prior anti-cancer vaccine (including

sipuleucel-T, Provenge®)

- Patient must not have received treatment with any of the following medications within

4 weeks of randomization or while on study:

- Systemic corticosteroids (excluding prednisone and dexamethasone administered as

part of study protocol); inhaled, intranasal or topical corticosteroids are acceptable; steroid eye drops are contraindicated however, for 2 weeks prior to vaccination and for at least 4 weeks after vaccinia vaccination


- Saw palmetto

- Megestrol

- Ketoconazole

- 5-alpha-reductase inhibitors - patients already taking 5-alpha-reductase

inhibitors prior to 28 days prior to randomization may stay on these agents throughout the course of therapy, but these should not be started while patients are on study

- Diethyl stilbestrol

- Any other hormonal agent or supplement with possible anti-cancer activity

- Patient must not have been treated with external beam radiation therapy within 4

weeks of randomization

- Patient must not have received prior radiation therapy to > 30% of bone marrow

- Patient must not have had surgery within 4 weeks of randomization

- Patient must not have received prior chemotherapy within 6 months of randomization;

prior and/or concurrent treatment with bisphosphonates, however, is permitted

- Patient must not have received prior chemotherapy for metastatic prostate cancer

- Patient cannot have a known history of human immunodeficiency virus (HIV) 1 or 2,

human T-lymphotropic virus (HTLV)-1, hepatitis B, or hepatitis C (or any other potentially immunosuppressive infection); eligible subjects must have negative serologic testing for HIV, hepatitis B surface antigen, and hepatitis C

- Patient cannot have a history of autoimmune disease requiring active

immunosuppressive therapy or have organ dysfunction >= grade 2 as a result of known autoimmune disease; eligible subjects must have antinuclear antibodies (ANA) titer < 1: 320

- Patient must not have undergone splenectomy

- Patient must not have other active malignancies other than non-melanoma skin cancers

or carcinoma in situ of the bladder; subjects with a history of other cancers who have been adequately treated and have been recurrence-free for >= 3 years are eligible

- Patient cannot have a known allergy to eggs

- Patient cannot have a known intolerance or allergic reactions to docetaxel or

compounds of similar chemical or biologic composition

- Patient cannot have a known history of allergy or intolerable reaction to a previous

vaccinia virus vaccination (e. g., smallpox)

- Patient or close household contacts of patient (those who share housing or have close

physical contact with the patient) cannot have close physical contact to persons with the following conditions within 3 weeks after potential vaccinia immunization:

- A history of eczema, active eczema or other acute, chronic or exfoliative skin

conditions, including Darier's disease (e. g. atopic dermatitis, burns, impetigo, varicella zoster, severe acne, or open wounds)

- Pregnant or nursing women

- Children under 3 years of age

- Immunodeficient or immunosuppressed persons (e. g. HIV, or treated for other

diseases with immunosuppressive agents)

- Any other moderate or severe acute illness until the illness resolves Patients

who would be unable to avoid these conditions for a 3-week period are not eligible; patients should also refer to the patient instruction sheet for vaccinia virus

- Patient cannot have known brain metastases

- Patient cannot have a known history of recent (within 6 months) stroke, myocardial

infarction, unstable angina, New York Heart Association class II-IV congestive heart failure, or significant cardiomyopathy requiring treatment

- Patient cannot take known strong inducers or inhibitors of cytochrome P450, family 3,

subfamily A, polypeptide 4 (CYP3A4) within 2 weeks of beginning docetaxel through its discontinuation; substrates of CYP3A4 with a narrow therapeutic/toxicity window may be used with caution, with prior approval of the study chair or institution's principal investigator (PI)

Locations and Contacts

Mayo Clinic in Florida, Jacksonville, Florida 32224-9980, United States

Hematology and Oncology Associates, Chicago, Illinois 60611, United States

Northwestern University, Chicago, Illinois 60611, United States

Hematology Oncology Associates of Illinois-Highland Park, Highland Park, Illinois 60035, United States

Presence Saint Mary's Hospital, Kankakee, Illinois 60901, United States

NorthShore Hematology Oncology-Libertyville, Libertyville, Illinois 60048, United States

Illinois Cancer Specialists-Niles, Niles, Illinois 60714, United States

Hematology Oncology Associates of Illinois - Skokie, Skokie, Illinois 60076, United States

Ochsner Medical Center Jefferson, New Orleans, Louisiana 70121, United States

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland 21287, United States

Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, United States

Mayo Clinic, Rochester, Minnesota 55905, United States

Laura and Issac Perlmutter Cancer Center at NYU Langone, New York, New York 10016, United States

University of Wisconsin Hospital and Clinics, Madison, Wisconsin 53792, United States

Additional Information

Starting date: August 2010
Last updated: July 28, 2015

Page last updated: August 23, 2015

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