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Intra-articular Betamethasone and the Hypothalamic-pituitary-adrenal Axis

Information source: The Nazareth Hospital, Israel
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Adrenal Suppression

Phase: N/A

Status: Completed

Sponsored by: The Nazareth Hospital, Israel

Official(s) and/or principal investigator(s):
George Habib, M.D., Principal Investigator, Affiliation: Nazareth Hospital

Summary

To evaluate the effect of intra-articular corticosteroid injection (IACI) of depot preparation of betamethasone on the hypothalamic-pituitary-adrenal (HPA) axis, in patients with osteoarthritis of the knee

Clinical Details

Official title: The Effect of Intra-articular Injection of Betamethasone Acetate/Betamethasone Sodium Phosphate at the Knee Joint on the Hypothalamic-pituitary-adrenal Axis: a Case Controlled Study

Study design: Observational Model: Case Control, Time Perspective: Prospective

Primary outcome: Adrenal Suppression

Secondary outcome:

favorable clinical response

Favorable clinical response

Detailed description: Consecutive patients attending the rheumatology or orthopedic clinic with osteoarthritic knee pain, not responding satisfactorily to medical or physical therapy were allocated to group-1 after consent and given IACI of 6 mg of betamethasone acetate/betamethasone sodium phosphate. Following completion of this part, consecutive age- and sex-matched patients were allocated to group-2 and given intra-articular injection of 60 mg of sodium hyaluronate. Just prior to the knee injection and 1, 2, 3, 4 and 8 weeks later, patients had 1 µg adrenocorticotropin hormone (ACTH) stimulation test. Secondary adrenal insufficiency (SAI) was defined as levels of less than 18 ng/ml or a rise of < than 7 ng/ml of serum cortisol, 30 minutes following the ACTH stimulation test.

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Osteoarthritis of the knee

Exclusion Criteria:

- Had steroids in the last 3 months. Allergic to steroids

Locations and Contacts

Additional Information

Starting date: October 2012
Last updated: February 23, 2013

Page last updated: August 23, 2015

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