Optimal Effect-site Concentration of Remifentanil for Inhibiting Response to Laryngeal Mask Airway (LMA) Removal
Information source: Yeungnam University College of Medicine
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Respiratory Complication
Intervention: Remifentanil (Drug)
Phase: N/A
Status: Completed
Sponsored by: Sangjin Park Official(s) and/or principal investigator(s):
sangjin park, M.D., Principal Investigator, Affiliation: Department of Anesthesiology and Pain Medicine, College of medicine, Yeungnam University, Daemyung-Dong, Nam-Gu, Daegu, Republic of Korea
Summary
This study was designed to determine the optimal dose of remifentanil that can prevent the
complications associated with the removal of LMA without delaying emergence.
Clinical Details
Official title: Optimal Effect-site Concentration of Remifentanil for Inhibiting Response to Laryngeal Mask Airway (LMA) Removal During Emergence From Sevoflurane-remifentanil Anesthesia
Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Prevention
Primary outcome: Number of Patients With Adverse Events Following LMA Removal
Detailed description:
Patients were randomly assigned to one of four groups. All patients received a predetermined
effect-site concentrations (Ce) of remifentanil by target-controlled infusion (TCI)
according to their group assignments (R0, remifentanil Ce of 0 ng/ml; R0. 5, remifentanil Ce
of 0. 5 ng/ml; R1. 0, remifentanil Ce of 1. 0 ng/ml; R1. 5, remifentanil Ce of 1. 5 ng/ml) from
10 minutes before the end of surgery to LMA removal. Airway complications (airway
obstruction, desaturation, breath holding, and coughing), nausea, and vomiting were assessed
during the emergence phase.
Eligibility
Minimum age: 18 Years.
Maximum age: 65 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- American Society of Anesthesiologists physical status 1 or 2
- undergoing lower extremity surgery under general anesthesia
Exclusion Criteria:
- suspected difficult airways
- respiratory disease (chronic obstructive pulmonary disease, upper respiratory
infection)
- body mass index > 30 kg/m2
- allergies to the study drugs
- a history of gastric reflux
Locations and Contacts
Additional Information
Starting date: July 2012
Last updated: August 21, 2014
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