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A Comparison of Olopatadine and Fluticasone in Patients With Allergic Conjunctivitis

Information source: Greiner, Jack V., OD DO PhD
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Conjunctivitis, Allergic

Intervention: Olopatadine (Drug); Fluticasone (Drug); Saline (Drug); Artificial tears (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: Greiner, Jack V., OD DO PhD

Official(s) and/or principal investigator(s):
Jack V Greiner, OD, DO, PhD, Principal Investigator, Affiliation: ORA, Inc.


To compare the clinical efficacy of olopatadine and fluticasone in a 3-week single center, double-masked, randomized, placebo controlled parallel treatment conjunctival allergen challenge (CAC) study in patients with allergic conjunctivitis

Clinical Details

Official title: A Comparison of Olopatadine Versus Fluticasone Nasal Spray in the Prevention of the Signs and Symptoms of Allergic Conjunctivitis

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: Ocular itching

Secondary outcome: Ocular redness

Detailed description: Study will evaluate the efficacy of nasal anti-allergic therapy compared to ocular anti-allergic therapy in the prevention of ocular allergic symptoms.


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- At least 18 years of age & either sex, any race

- Willing and able to follow all instructions and attend all study visits

- Positive history of ocular allergies

- Reproducible positive ocular allergic reaction induced by conjunctival allergen

challenge Exclusion Criteria:

- Have planned surgery during trial period

- Female currently pregnant, planning a pregnancy, or lactating

- Use of disallowed medications

Locations and Contacts

Ophthalmic Research Associates, Inc, North Andover, Massachusetts 01845, United States
Additional Information

Starting date: February 2008
Last updated: April 2, 2008

Page last updated: August 23, 2015

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