Effect of Remifentanil on Cough During Emergence From General Anesthesia : Trial to Compare Between Sevoflurane Anesthesia and Propofol Anesthesia
Information source: Yonsei University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Elective Thyroidectomy
Intervention: Remifentanil (Drug)
Phase: Phase 4
Status: Completed
Sponsored by: Yonsei University Official(s) and/or principal investigator(s):
Jeong-Rim Lee, MD, Ph.D, Principal Investigator, Affiliation: Severance Hospital, Department of Anesthesiology and Pain Medicine
Summary
The objective of this study was to compare the effect of remifentanil on suppression cough
reflex during emergence in patient anesthetized using either propofol or sevoflurane
additionally under infusion of the identical concentration of remifentanil.
Clinical Details
Official title: Effect of Remifentanil on Cough During Emergence From General Anesthesia : Randomized Trial to Comparison Between Sevoflurane Anesthesia and Propofol Anesthesia
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention
Detailed description:
During recovery from general anesthesia the stimuli of endotracheal tube lead to the
coughing, hypertension, tachycardia, which can cause a serious complication.
It has been demonstrated that opioid, intravenous or topical lidocaine administration can
attenuate the coughing reflex.
Administered the opioid before emergence, it is effective to prevent cough reflex but the
recovery is delayed, it was difficult to predict emergence.
However, remifentanil is an opioid widely used because of rapid context-sensitive half-life,
target-controled infusion method to adequately maintain the effect site concentration could
help to predict the recovery time to the alert state from the general anesthesia. It is
considered proper method of continuous infusion of remifentanil for reducing emergence
cough.
Recent reporters suggest that antitussive effect of remifentanil differs depend on main
anesthetic agents, the incidence of coughing when tracheal extubation is reduced after
propofol anesthesia compared with sevoflurane anesthesia.
However, these studies raise important questions about failure of maintaining the same
effect site concentration of remifentanil in both groups.
The objective of this study was to compare the effect of remifentanil on suppression cough
reflex during emergence in patient anesthetized using either propofol or sevoflurane
additionally under infusion of the identical concentration of remifentanil.
During recovery from general anesthesia the stimuli of endotracheal tube lead to the
coughing, hypertension, tachycardia, which can cause a serious complication.
It has been demonstrated that opioid, intravenous or topical lidocaine administration can
attenuate the coughing reflex.
Administered the opioid before emergence, it is effective to prevent cough reflex but the
recovery is delayed, it was difficult to predict emergence.
However, remifentanil is an opioid widely used because of rapid context-sensitive half-life,
target-controled infusion method to adequately maintain the effect site concentration could
help to predict the recovery time to the alert state from the general anesthesia. It is
considered proper method of continuous infusion of remifentanil for reducing emergence
cough.
Recent reporters suggest that antitussive effect of remifentanil differs depend on main
anesthetic agents, the incidence of coughing when tracheal extubation is reduced after
propofol anesthesia compared with sevoflurane anesthesia.
However, these studies raise important questions about failure of maintaining the same
effect site concentration of remifentanil in both groups.
The objective of this study was to compare the effect of remifentanil on suppression cough
reflex during emergence in patient anesthetized using either propofol or sevoflurane
additionally under infusion of the identical concentration of remifentanil.
Eligibility
Minimum age: 20 Years.
Maximum age: 70 Years.
Gender(s): Female.
Criteria:
Inclusion Criteria:
- females
- ASA I-II
- aged between 20 and 70 year
- general anesthesia for elective thyroidectomy
Exclusion Criteria:
- signs of an anatomical or functional abnormality in upper airway
- risk factors for perioperative aspiration
- smoking for recent 8 weeks
- URI or sore throat for recent 2 weeks
- potential of pregnancy
Locations and Contacts
Severance Hospital, Seoul 120-752, Korea, Republic of
Additional Information
Starting date: September 2010
Last updated: May 12, 2011
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