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Rate Control in Atrial Fibrillation: A Randomized, Double-Blind, Crossover Comparison of Carvedilol and Metoprolol Tartrate

Information source: Creighton University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Atrial Fibrillation

Intervention: Carvedilol (Drug); Metoprolol tartrate (Drug)

Phase: Phase 4

Status: Not yet recruiting

Sponsored by: Creighton University

Overall contact:
Caroline Nubel, Phone: (402) 280-4032, Email: carolinenubel@creighton.edu


This study will evaluate the efficacy of metoprolol tartrate compared to carvedilol on heart rate control in patients with atrial fibrillation and a rapid ventricular rate.

Clinical Details

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: Resting heart rate


Minimum age: 19 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- Permanent atrial fibrillation

- Baseline ventricular rate (prior to treatment) > 110 bpm

Exclusion Criteria:

- History of accessory tract re-entry tachycardia

- Ejection fraction < 35% or history of NYHA Class III/IV stage C/D heart failure

- Acute coronary syndrome, percutaneous coronary intervention, or cardiac surgery in

the past 2 months

- Child-Pugh class B or C hepatic dysfunction

- Uncontrolled hypertension

- Thyroid disease

- Intolerance to beta-blockers

- History of lung disease resulting in hospitalization in the past year

Locations and Contacts

Caroline Nubel, Phone: (402) 280-4032, Email: carolinenubel@creighton.edu

Creighton University, Omaha, Nebraska 68178, United States; Recruiting
Caroline Nubel, Phone: 402-280-4032, Email: carolinenubel@creighton.edu
Pallavi Bellamkonda, MBBS, Principal Investigator
Additional Information

Starting date: April 2015
Last updated: March 24, 2015

Page last updated: August 23, 2015

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