Sex Steroids, Obesity and Lipids in Adolescent Females
Information source: National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Cardiovascular Diseases; Heart Diseases; Obesity; Hypercholesterolemia
Phase: N/A
Status: Completed
Sponsored by: National Heart, Lung, and Blood Institute (NHLBI)
Summary
To prospectively explore the relationships of endogenous sex steroid hormones and obesity
and their interactions with lipoprotein cholesterol and apolipoprotein levels in nine and
ten year old Black and white adolescent girls for five years during puberty.
Clinical Details
Study design: N/A
Detailed description:
BACKGROUND:
In 1987, there was growing evidence that androgens, particularly when elevated, had an
unfavorable effect on lipo/apo levels, tending to lower HDL cholesterol (HDLC) and raise LDL
cholesterol (LDLC). Previous studies confirmed that although pre-pubertal boys and girls
had similar lipo/apo levels, post-pubertal boys had a higher ratio of LDLC/HDLC than girls,
in part because of their androgen levels. Such lipo/apo levels had been associated with an
increased risk of coronary heart disease. There was also evidence that obese girls tended
to be hyperandrogenic and thus had unfavorable lipo/apo levels and a higher risk of coronary
heart disease. This study sought to elucidate whether high androgen levels preceded or were
a consequence of obesity.
DESIGN NARRATIVE:
The longitudinal study was ancillary to the National Growth and Health Study (NGHS), a
multicenter study which investigated the occurrence of obesity in Black and white adolescent
girls, predictors of the transition to the obese state, the correlates of the transition,
and the relationship of the transition to other coronary heart disease risk factors. As
part of the NGHS, participants from the Cincinnati, Ohio and Washington, D. C. public and
parochial schools received physical examinations with attention to pubertal staging and
anthropometric measurements including weight, height, and skinfold thickness. Along with
NGHS blood samples, additional blood was obtained in years 1, 3, and 5 for measurements of
lipids, lipoprotein cholesterols, apolipoproteins A1, A2, and B, and sex steroid hormones
including plasma total and free testosterone, dehydroepiandrosterone sulfate, estradiol, and
testosterone estrogen binding globulin.
Eligibility
Minimum age: N/A.
Maximum age: N/A.
Gender(s): Male.
Criteria:
No eligibility criteria
Locations and Contacts
Additional Information
Related publications: Lucky AW, Biro FM, Huster GA, Leach AD, Morrison JA, Ratterman J. Acne vulgaris in premenarchal girls. An early sign of puberty associated with rising levels of dehydroepiandrosterone. Arch Dermatol. 1994 Mar;130(3):308-14.
Starting date: September 1987
Last updated: June 23, 2005
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