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Comparing the Effects of Two Beta Blockers,Metoprolol and Nebivolol,on Ambulatory Blood Pressure and Basal Metabolic Rate

Information source: University of Mississippi Medical Center
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Hypertension

Intervention: Metoprolol (Drug); Nebivolol (Drug)

Phase: N/A

Status: Terminated

Sponsored by: University of Mississippi Medical Center

Official(s) and/or principal investigator(s):
Deborah Minor, PharmD, Principal Investigator, Affiliation: University of Mississippi Medical Center


The purpose of the study is to compare the effects of nebivolol and metoprolol on 24-hour ambulatory blood pressure characteristics and basal metabolic rates in patients with hypertension.

Clinical Details

Official title: Comparative Effects of Nebivolol Versus Metoprolol on 24-hour Blood Pressures and Basal Metabolic Rate: An Open-Label Study

Study design: Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Primary Outcome is Pre- and Post-treatment Ambulatory Blood Pressure.


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- 18 years old or older

- currently be treated at a University of MS Medical Center Internal Medicine Clinics

- currently taking metoprolol succinate for hypertension

- have their hypertension controlled (<140/90).

Exclusion Criteria:

- uncontrolled hypertension

- severe renal or moderate hepatic impairment

- currently taking CYP 2D6 inducers/inhibitors

- recent stroke (less than 6 months)

- recent myocardial infarction (less than 6 months)

- congestive heart failure

- diagnosed obstructive sleep apnea

- atrial fibrillation

- arm circumference >50 cm

Locations and Contacts

University of Mississippi Medical Center, Jackson, Mississippi 39216, United States
Additional Information

Starting date: January 2009
Last updated: March 18, 2013

Page last updated: August 23, 2015

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