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Study of Rocuronium Onset Time According to Remifentanil Infusion

Information source: Seoul National University Bundang Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Anesthesia

Intervention: the order of drug administration (Drug)

Phase: N/A

Status: Completed

Sponsored by: Seoul National University Bundang Hospital

Summary

The investigators therefore hypothesized that remifentanil could prolong the onset time of rocuronium, and evaluated the effect of remifentanil on the hemodynamic profiles (arterial pressure and heart rate) during the anesthetic induction sequence.

Clinical Details

Official title: The Effect of Remifentanil on the Onset Time of Rocuronium in Total Intravenous Anesthesia

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)

Primary outcome: the onset time of rocuronium

Secondary outcome:

mean arterial pressure (MAP)

heart rate (HR)

cardiac output

pain from the propofol infusion

cough or chest wall rigidity from the remifentanil infusion

Detailed description: It has been reported that co-administration of ephedrine reduced the onset time of neuromuscular block of rocuronium (1-3). It also provided an improved condition for the rapid tracheal intubation (2,4). This beneficial effect was attributed to the increased cardiac output and tissue perfusion to muscle, and therefore, a more rapid delivery of rocuronium to the neuromuscular junction was achieved (4-5). If so, any drugs which decrease cardiac output consequently can prolong the onset time of rocuronium. Remifentanil is the first ultra-short acting opioid with a rapid onset. During the total intravenous anesthesia (TIVA) with propofol and remifentanil, prior administration of remifentanil could reduce the propofol infusion pain without other significant complications (6). However, remifentanil can decrease the arterial pressure and heart rate (7-8), so that it is likely to decrease the onset time of rocuronium for the opposite principle that ephedrine increases it. The investigators therefore hypothesized that remifentanil could prolong the onset time of rocuronium, and evaluated the effect of remifentanil on the hemodynamic profiles (arterial pressure and heart rate) during the anesthetic induction sequence.

Eligibility

Minimum age: 20 Years. Maximum age: 65 Years. Gender(s): Both.

Criteria:

Inclusion criteria:

- American Society of Anesthesiologist physical status I or II

- Aged 20-65 yr

- Elective surgery under general anesthesia with total intravenous anesthesia

- 8. 5 kg/m2 < body mass index (BMI) < 25 kg/m2

Exclusion criteria:

- BMI > 25 kg/m2 or < 18. 5 kg/m2

- Any cardiovascular or neuromuscular disease

- Intake of drugs known to interact with the neuromuscular junction

- Patients wit risk of pulmonary aspiration

- Anticipated difficult airway

- history of known allergy to rocuronium

Locations and Contacts

Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do 463-707, Korea, Republic of
Additional Information

Starting date: December 2009
Last updated: December 14, 2011

Page last updated: August 23, 2015

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