Study of Rocuronium Onset Time According to Remifentanil Infusion
Information source: Seoul National University Bundang Hospital
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Anesthesia
Intervention: the order of drug administration (Drug)
Phase: N/A
Status: Completed
Sponsored by: Seoul National University Bundang Hospital
Summary
The investigators therefore hypothesized that remifentanil could prolong the onset time of
rocuronium, and evaluated the effect of remifentanil on the hemodynamic profiles (arterial
pressure and heart rate) during the anesthetic induction sequence.
Clinical Details
Official title: The Effect of Remifentanil on the Onset Time of Rocuronium in Total Intravenous Anesthesia
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Primary outcome: the onset time of rocuronium
Secondary outcome: mean arterial pressure (MAP)heart rate (HR) cardiac output pain from the propofol infusion cough or chest wall rigidity from the remifentanil infusion
Detailed description:
It has been reported that co-administration of ephedrine reduced the onset time of
neuromuscular block of rocuronium (1-3). It also provided an improved condition for the
rapid tracheal intubation (2,4). This beneficial effect was attributed to the increased
cardiac output and tissue perfusion to muscle, and therefore, a more rapid delivery of
rocuronium to the neuromuscular junction was achieved (4-5). If so, any drugs which decrease
cardiac output consequently can prolong the onset time of rocuronium.
Remifentanil is the first ultra-short acting opioid with a rapid onset. During the total
intravenous anesthesia (TIVA) with propofol and remifentanil, prior administration of
remifentanil could reduce the propofol infusion pain without other significant complications
(6). However, remifentanil can decrease the arterial pressure and heart rate (7-8), so that
it is likely to decrease the onset time of rocuronium for the opposite principle that
ephedrine increases it.
The investigators therefore hypothesized that remifentanil could prolong the onset time of
rocuronium, and evaluated the effect of remifentanil on the hemodynamic profiles (arterial
pressure and heart rate) during the anesthetic induction sequence.
Eligibility
Minimum age: 20 Years.
Maximum age: 65 Years.
Gender(s): Both.
Criteria:
Inclusion criteria:
- American Society of Anesthesiologist physical status I or II
- Aged 20-65 yr
- Elective surgery under general anesthesia with total intravenous anesthesia
- 8. 5 kg/m2 < body mass index (BMI) < 25 kg/m2
Exclusion criteria:
- BMI > 25 kg/m2 or < 18. 5 kg/m2
- Any cardiovascular or neuromuscular disease
- Intake of drugs known to interact with the neuromuscular junction
- Patients wit risk of pulmonary aspiration
- Anticipated difficult airway
- history of known allergy to rocuronium
Locations and Contacts
Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do 463-707, Korea, Republic of
Additional Information
Starting date: December 2009
Last updated: December 14, 2011
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