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Branched Chain Amino Acid Plus Glucose Supplement Reduces Exercise-Induced Delayed Onset Muscle Soreness in College Females

Information source: University of Vermont
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Exercise-induced Delayed Onset Muscle Soreness

Intervention: Branched Chain Amino Acid drink supplement (Dietary Supplement); Placebo (Dietary Supplement)

Phase: N/A

Status: Completed

Sponsored by: University of Vermont

Official(s) and/or principal investigator(s):
Stephen J Pintauro, Ph.D., Principal Investigator, Affiliation: University of Vermont


The purpose of this study is to determine if a dietary supplement containing branched chain amino acids will reduce the muscle soreness that sometimes occurs in the days following exercise.

Clinical Details

Official title: The Effects of Branched Chain Amino Acid and Nutrient Supplementation on Exercise-Induced Delayed Onset Muscle Soreness in College Females

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Supportive Care

Primary outcome: Delayed Onset Muscle Soreness Rating Scale

Detailed description: Supplementation with branched chain amino acids (BCAAs) has been used to stimulate muscle protein synthesis following exercise. The purpose of this study was to determine if supplementation with BCAAs in combination with glucose would reduce exercise-induced delayed onset muscle soreness (DOMS). Using a double-blind crossover design, 20 subjects (11 females, 9 males) were randomly assigned to either BCAA (n=10) or placebo (n=10) groups. Subjects performed a squatting exercise to elicit DOMS and rated their muscle soreness every 24 hours for four days following exercise while continuing to consume the BCAA or placebo. Following a three-week recovery period, subjects returned and received the alternate BCAA or placebo treatment, repeating the same exercise and DOMS rating protocol for the next four days. BCAA supplementation in female subjects resulted in a significant decrease in DOMS versus placebo at 24 hours following exercise (p = 0. 018). No significant effect of BCAA supplementation versus placebo was noted in male subjects, nor when male and female results were analyzed together. This gender difference may be related to dose per body weight differences between male and female subjects.


Minimum age: 18 Years. Maximum age: 25 Years. Gender(s): Both.


Inclusion Criteria:

- Men (n=9) and women (n=11) aged 18-25 who engaged in no more than one hour of light

to moderate intensity physical activity per week were recruited from the Greater Burlington, Vermont area. Exclusion Criteria:

- individuals who engaged in more than one hour per week of light to moderate physical


- had been involved in strict athletic competition or weight training in the past six


- were pregnant or nursing, had a known muscular disease, diabetes mellitus,

cardiovascular disease, respiratory disease, and/or were currently taking a protein-based dietary supplement

Locations and Contacts

University of Vermont, Burlington, Vermont 05405, United States
Additional Information

Starting date: September 2011
Last updated: January 31, 2013

Page last updated: August 23, 2015

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