DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Drug Interaction Between Irbesartan and Hydrochlorothiazide

Information source: Damanhour University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Healthy

Intervention: Irbeasartan/hydrochlorothiazide (Drug); Irbesartan (Drug); Hydrochlorothiazide (Drug)

Phase: N/A

Status: Completed

Sponsored by: Damanhour University


This study was conducted to investigate any potential reaction between irbesartan and hydrochlorothiazide.

Clinical Details

Study design: Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Crossover Assignment, Masking: Open Label

Primary outcome:

Blood pressure (systolic/diastolic)

pharmacokinetic parameter such as the Cmax of irbesartan and hydrochlorothiazide

Heart rate

pharmacokinetic parameter such as the AUC of irbesartan and hydrochlorothiazide


Minimum age: 18 Years. Maximum age: 45 Years. Gender(s): Male.


Inclusion Criteria: At least 18 years old and not more than 45 healthy normotensive male volunteers Who had passed all the screening parameters Exclusion Criteria: A clinically significant abnormal physical exam, medical history, or laboratory studies If they showed a sitting SBP of >140 or <100 mmHg, DBP > 90 or <60mm Hg, or a pulse rate of > 95 or < 50 beats/min at screening The use of any prescription drug within the previous month or use of any over-the-counter medication within the past 14 days A history of blood dyscrasias A history of alcohol or drug abuse within the past year Donation of blood during the 8 weeks prior to the study or plans to donate blood during or within 8 weeks of completing the study Unable to tolerate vein puncture and multiple blood samplings Any surgical/medical condition that might alter drug absorption, distribution, metabolism, or excretion

Locations and Contacts

Pharmaceutics Department, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt
Additional Information

Starting date: March 2013
Last updated: May 24, 2013

Page last updated: August 23, 2015

-- advertisement -- The American Red Cross
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017