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Antitussive Effect of a Naturally Flavored Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo

Information source: Montefiore Medical Center
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Cough Reflex Sensitivity

Intervention: diphenhydramine/phenylephrine/cocoa; dextromethorophan; placebo (Drug); diphenhydramine/phenylephrine/cocoa; placebo; dextromethorphan (Drug); dextromethorphan; diphenhydramine/phenylephrine/cocoa; placebo (Drug); dextromethorophan; placebo; diphenhydramine/phenylephrine/cocoa (Drug); placebo; diphenhydramine/phenylephrine/cocoa; dextromethorphan (Drug); placebo; dextromethorphan; diphenhydramine/phenylephrine/cocoa (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: Montefiore Medical Center


The purpose of this study is to evaluate the antitussive (cough-suppressing) effects of two liquid medications: a combination of diphenhydramine and phenylephrine in a naturally cocoa flavoring, and, dextromethorphan syrup, compared with placebo.

Clinical Details

Official title: Antitussive Effect of a Naturally Flavored, Multi-Component Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Primary outcome: Change in Cough Reflex Sensitivity to Capsaicin


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- healthy adult nonsmokers

- onset of acute, viral upper respiratory tract infection (common cold) within 72

hours of enrollment Exclusion Criteria:

- smokers

- history of asthma or other respiratory disorders

Locations and Contacts

Einstein Division/Montefiore Medical Center, Bronx, New York 10461, United States
Additional Information

Starting date: January 2014
Last updated: April 8, 2015

Page last updated: August 23, 2015

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