Antitussive Effect of a Naturally Flavored Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo
Information source: Montefiore Medical Center
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Cough Reflex Sensitivity
Intervention: diphenhydramine/phenylephrine/cocoa; dextromethorophan; placebo (Drug); diphenhydramine/phenylephrine/cocoa; placebo; dextromethorphan (Drug); dextromethorphan; diphenhydramine/phenylephrine/cocoa; placebo (Drug); dextromethorophan; placebo; diphenhydramine/phenylephrine/cocoa (Drug); placebo; diphenhydramine/phenylephrine/cocoa; dextromethorphan (Drug); placebo; dextromethorphan; diphenhydramine/phenylephrine/cocoa (Drug)
Phase: Phase 4
Status: Completed
Sponsored by: Montefiore Medical Center
Summary
The purpose of this study is to evaluate the antitussive (cough-suppressing) effects of two
liquid medications: a combination of diphenhydramine and phenylephrine in a naturally cocoa
flavoring, and, dextromethorphan syrup, compared with placebo.
Clinical Details
Official title: Antitussive Effect of a Naturally Flavored, Multi-Component Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
Primary outcome: Change in Cough Reflex Sensitivity to Capsaicin
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- healthy adult nonsmokers
- onset of acute, viral upper respiratory tract infection (common cold) within 72
hours of enrollment
Exclusion Criteria:
- smokers
- history of asthma or other respiratory disorders
Locations and Contacts
Einstein Division/Montefiore Medical Center, Bronx, New York 10461, United States
Additional Information
Starting date: January 2014
Last updated: April 8, 2015
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