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Comparison Between Erythromycin and Neomycin Treatment of Hepatic Encephalopathy

Information source: UPECLIN HC FM Botucatu Unesp
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Hepatic Encephalopathy; Hypertension, Portal; Liver Cirrhosis

Intervention: Erythromycin (Drug); Neomycin (Drug)

Phase: N/A

Status: Active, not recruiting

Sponsored by: UPECLIN HC FM Botucatu Unesp

Official(s) and/or principal investigator(s):
Fernando G Romeiro, Principal Investigator, Affiliation: Faculdade de Medicina de Botucatu - UNESP
Carlos A Caramori, Study Chair, Affiliation: Faculdade de Medicina de Botucatu - UNESP

Summary

Comparison between the efficacy of two different antibiotics in patients with overt hepatic encephalopathy. The study is randomized, controlled and double-blinded.

Clinical Details

Official title: Erythromycin Versus Neomycin Treatment for Overt Hepatic Encephalopathy: a Double-blind, Randomised, Controlled Trial.

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Factorial Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Primary outcome: Recovery of hepatic encephalopathy

Secondary outcome: length of hospitalization caused by hepatic encephalopathy

Eligibility

Minimum age: 18 Years. Maximum age: 80 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Hepatic cirrhosis or portal hypertension

- Hepatic Encephalopathy

Exclusion Criteria:

- Acute liver failure

- Neuropsychiatric diseases

- Inflammatory bowel diseases

- Intestinal obstruction

- Shock

- Renal insufficiency

- Alcoholic hepatitis

- Alcohol abuse

- Antibiotic premedication

Locations and Contacts

Faculdade de Medicina de Botucatu - Universidade Estadual Paulista, Botucatu, São Paulo 18618970, Brazil
Additional Information

Starting date: June 2008
Last updated: April 27, 2010

Page last updated: August 23, 2015

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