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A Comparison of Propofol Based Total Intravenous Anesthesia and Desflurane Based Balanced Anesthesia on Renal Protection During Deceased Brain Dead Donor Kidney Transplantation - A Prospective, Randomized Trial

Information source: Yonsei University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: End Stage Renal Disease

Intervention: Desflurane balanced anesthesia (Drug); Propofol total intravenous anesthesia (Drug)

Phase: Phase 4

Status: Recruiting

Sponsored by: Yonsei University

Overall contact:
Young Chul Yoo, MD, Phone: 82-2-2228-2420, Email: seaoyster@yuhs.ac

Summary

Renal ischemia/reperfusion (I/R)-induced injury is known to be associated with immediate and long-term kidney dysfunction after renal transplantation. Protecting the kidney against I/R injury and maintaining renal function during renal transplant surgery is therefore very important in order to improve post-operative outcome. This purpose of this study is to investigate whether propofol anesthesia done in both kidney donors and recipients during deceased brain dead donor kidney transplantation is effective in reducing renal I/R injury via its antioxidant and antiinflammatory properties and improve post-transplant outcome compared to desflurane anesthesia.

Clinical Details

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Primary outcome: The difference in inflammatory markers of recipients between groups during and after renal transplantation (CRP, WBC differential count, IL-6, TGF-β)

Secondary outcome: The difference in renal function of kidney recipients between groups after renal transplantation (BUN/Cr, cystatin C, NGAL)

Eligibility

Minimum age: 20 Years. Maximum age: 69 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Adult deceased brain dead kidney donors and recipients scheduled for renal

transplantation Exclusion Criteria: 1. Donor exclusion criteria: (1) Refusal of legal guardian 2. Recipient exclusion criteria: 1. Patient refusal 2. Hypersensitivity to propofol, soybeans or peanuts 3. History of vitamin C or E intake within 5 days before surgery 4. History of acute myocardial infarct within 6 months before surgery 5. Congestive heart failure (NYHA III-IV) 6. Autoimmune disease patients 7. BMI over 30 kg/m2 8. Left ventricular ejection fraction less than 35% upon preoperative echocardiography

Locations and Contacts

Young Chul Yoo, MD, Phone: 82-2-2228-2420, Email: seaoyster@yuhs.ac

Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul 120-752, Korea, Republic of; Recruiting
Young Chul Yoo, MD
Additional Information

Starting date: October 2013
Last updated: July 24, 2014

Page last updated: August 23, 2015

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