A Comparison of Propofol Based Total Intravenous Anesthesia and Desflurane Based Balanced Anesthesia on Renal Protection During Deceased Brain Dead Donor Kidney Transplantation - A Prospective, Randomized Trial
Information source: Yonsei University
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: End Stage Renal Disease
Intervention: Desflurane balanced anesthesia (Drug); Propofol total intravenous anesthesia (Drug)
Phase: Phase 4
Status: Recruiting
Sponsored by: Yonsei University Overall contact: Young Chul Yoo, MD, Phone: 82-2-2228-2420, Email: seaoyster@yuhs.ac
Summary
Renal ischemia/reperfusion (I/R)-induced injury is known to be associated with immediate and
long-term kidney dysfunction after renal transplantation. Protecting the kidney against I/R
injury and maintaining renal function during renal transplant surgery is therefore very
important in order to improve post-operative outcome. This purpose of this study is to
investigate whether propofol anesthesia done in both kidney donors and recipients during
deceased brain dead donor kidney transplantation is effective in reducing renal I/R injury
via its antioxidant and antiinflammatory properties and improve post-transplant outcome
compared to desflurane anesthesia.
Clinical Details
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention
Primary outcome: The difference in inflammatory markers of recipients between groups during and after renal transplantation (CRP, WBC differential count, IL-6, TGF-β)
Secondary outcome: The difference in renal function of kidney recipients between groups after renal transplantation (BUN/Cr, cystatin C, NGAL)
Eligibility
Minimum age: 20 Years.
Maximum age: 69 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Adult deceased brain dead kidney donors and recipients scheduled for renal
transplantation
Exclusion Criteria:
1. Donor exclusion criteria:
(1) Refusal of legal guardian
2. Recipient exclusion criteria:
1. Patient refusal
2. Hypersensitivity to propofol, soybeans or peanuts
3. History of vitamin C or E intake within 5 days before surgery
4. History of acute myocardial infarct within 6 months before surgery
5. Congestive heart failure (NYHA III-IV)
6. Autoimmune disease patients
7. BMI over 30 kg/m2
8. Left ventricular ejection fraction less than 35% upon preoperative echocardiography
Locations and Contacts
Young Chul Yoo, MD, Phone: 82-2-2228-2420, Email: seaoyster@yuhs.ac
Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul 120-752, Korea, Republic of; Recruiting Young Chul Yoo, MD
Additional Information
Starting date: October 2013
Last updated: July 24, 2014
|