The Effects of Different Clonidine Concentrations on Axillary Brachial Plexus Block With 1,5% Lidocaine
Information source: Universidade Federal do Rio de Janeiro
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Fascicular Block; Motor Activity; Pain, Postoperative; Latency Period
Intervention: high Clonidine concentration (Drug); low clonidine concentration (Drug); Lidocaine (Drug); Lidocaine 40 ml (Drug)
Phase: Phase 2
Status: Completed
Sponsored by: Universidade Federal do Rio de Janeiro
Summary
The purpose of this study is to determine whether different clonidine concentration on
axillary brachial plexus block with 1,5% lidocaine for upper limb surgery may influence the
sensory and motor block onset time and duration, postoperative analgesia duration,
postoperative pain intensity
Clinical Details
Official title: The Effects of Different Clonidine Concentrations on Axillary Brachial Plexus Block With 1,5% Lidocaine for Upper Limb Surgery: a Prospective Randomized Study
Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Caregiver), Primary Purpose: Treatment
Primary outcome: sensorial and motor block duration
Secondary outcome: adverse effects of additive clonidine on axillary brachial plexus block in upper limb surgerypostoperative analgesia duration sensorial and motor block onset time postoperative pain intensity
Detailed description:
Brachial plexus blocks are frequently used in surgical procedures involving the upper limb
because they facilitate surgical anaesthesia, muscle relaxation and post-operative
analgesics.
Various drugs are used to supplement local anaesthetics during brachial plexus block. Many
studies in the literature show that clonidine, which is an alpha-2 agonist, prolongs the
length of anesthesia and post-operative analgesia. 4,5 However, clonidine's side
effects—such as hypotension, bradycardia and sedation can limit its use.
There are no studies comparing different clonidine concentrations on the axillary brachial
block, so the hypothesis of the present study was that different clonidine concentrations
and LA volumes may influence the anaesthesia and analgesia quality on this type of regional
block.
Eligibility
Minimum age: 18 Years.
Maximum age: 65 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- both genders,
- over 18 years old,
- American Society of Anesthesiologists (ASA) 1 to 3
Exclusion Criteria:
- patients with chronic use of analgesics and non-steroidal anti-inflammatories drugs,
- pregnant,
- with infection at the puncture site,
- coagulopathies or intolerance to drugs used in the study
Locations and Contacts
Additional Information
Starting date: February 2009
Last updated: June 14, 2012
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