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Efficacy of Preoperative Intravenous Dexamethasone in Primary Total Knee Arthroplasty

Information source: Thammasat University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Postoperative Pain

Intervention: Dexamethasone (Drug); Normal saline (Drug)

Phase: Phase 4

Status: Recruiting

Sponsored by: Thammasat University

Official(s) and/or principal investigator(s):
Supakit Kanitnate, M.D., Principal Investigator, Affiliation: Orthopaedics department, Thammasat University

Overall contact:
Supakit Kanitnate, M.D., Phone: 6629269775, Email: naypeng@hotmail.com


To determine efficacy of preoperative IV dexamethasone for postoperative pain control after TKA.

Clinical Details

Official title: Efficacy of Preoperative Intravenous Dexamethasone in Controlling Postoperative Pain After Primary Total Knee Arthroplasty: A Randomized Double-blinded Controlled Trial

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: post-operative pain

Secondary outcome:

Functional knee score

post-operative nausea and vomiting

complication of preoperative dexamethasone

Detailed description: Preoperative intravenous over 0. 1 mg/kg of dexamethasone could be reduced pain after primary TKA.


Minimum age: 50 Years. Maximum age: 85 Years. Gender(s): Both.


Inclusion Criteria:

- Osteoarthritis of the knee who undergoing unilateral primary total knee arthroplasty

- 50-85 years old

- ASA class 1-3

Exclusion Criteria:

- Unable to perform spinal anaesthesia

- History of drug allergies: steroids

- Renal impairment (CrCl <30 mL/min)

- Liver impairment

- Cognitive function disorders

- Poor controlled DM (HA1C > 7. 5)

- Morning DTX at operative day > 180 mg%

- Received corticosteroids within 3 months before surgery

Locations and Contacts

Supakit Kanitnate, M.D., Phone: 6629269775, Email: naypeng@hotmail.com

Orthopaedic department, Faculty of medicine, Thammasat university, Klongluang, Pathumthani 066, Thailand; Recruiting
supakit kanitnate, Phone: 6629269775, Email: naypeng@hotmail.com
Additional Information

Starting date: March 2014
Last updated: April 4, 2014

Page last updated: August 23, 2015

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