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Effect-site Concentration of Remifentanil for Smooth Induction With Desflurane

Information source: Ajou University School of Medicine
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Anesthesia

Intervention: Remifentanil (Drug); Desflurane (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: Ajou University School of Medicine

Official(s) and/or principal investigator(s):
Yoonjeong Chae, MD, Study Chair, Affiliation: Ajou University School of Medicine


Desflurane is a halogenated ether with low solubility, giving rapid induction and emergence from anesthesia This character is suitable for Volatile Induction and Maintenance Anesthesia (VIMA). But desflurane can cause airway irritation when it used as a sole induction agent to adult or children, so there were many studies about reducing the airway reflex combined with desflurane. Remifentanil is a short acting opioid and is quickly hydrolyzed by nonspecific esterase in the plasma and multiorgan. Several studies suggest the optimal dose of remifentanil for reducing airway reflex or cardiovascular response for intubation combined with desflurane. But these studies were under 1 Minimal Alveolar Concentration (MAC) of desflurane and this point could be a limitation because desflurane concentration over 1 MAC increase airway irritation significantly. This study this study was designed to determine a median effective effect-site concentration (EC50) of remifentanil to prevent airway irritation during desflurane anesthesia over 1 MAC.

Clinical Details

Official title: Effect-site Concentration of Remifentanil for Smooth Induction With Desflurane

Study design: Intervention Model: Single Group Assignment, Masking: Single Blind (Investigator)

Primary outcome: Fail or success for induction with desflurane


Minimum age: 19 Years. Maximum age: 60 Years. Gender(s): Both.


Inclusion Criteria:

- patients for surgery requiring general anesthesia

- American Society of Anesthesiologists(ASA) classification I, II

Exclusion Criteria:

- history of gastroesophageal reflux, High grade obesity, Predicted difficult airway,

Asthma, Chronic obstructive pulmonary disease(COPD), Upper respiratory infection (URI) within 3 weeks

Locations and Contacts

Additional Information

Starting date: December 2014
Last updated: August 17, 2015

Page last updated: August 23, 2015

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