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Insulin Sensitivity and Metabolism Before and After Treatment in Patients With Hypothyroidism

Information source: University of Aarhus
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Hypothyroidism

Intervention: Levothyroxin (Drug)

Phase: N/A

Status: Terminated

Sponsored by: University of Aarhus


The aim of this study is to further characterize the treatment related changes in insulin sensitivity, substrate metabolism and intra hepatic- and intramyocellular lipid content in patients with hypothyroidism

Clinical Details

Official title: Insulin Sensitivity and Metabolism Before and After Treatment in Patients With Hypothyroidism

Study design: Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Primary outcome:

intracellular lipid content in liver and muscle

intraabdominal lipid content

insulin sensitivity

substrate metabolism

intracellular signaling in the basal state and during insulin stimulation


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- written informed consent

- must be of legal age and competent

- Age > 18 years

- presently diagnosed with hypothyroidism

Exclusion Criteria:

- alcohol consumption >21 units per week

- Malignant disease

- pregnancy

- magnetic implants or material in the body

- BMI > 30

- Heart disease (NYHA >2)

- Uncontrolled hypertension

- Manifest diabetes mellitus

- Changes in medication, with any influence on glucose metabolism, 2 months prior to

and until the end of the trial.

Locations and Contacts

Medical department M (Endocrinology and Diabetes), Aarhus University Hospital, Aarhus Sygehus,, Aarhus 8000, Denmark
Additional Information

(Danish Data Protection Agency)

Starting date: January 2010
Last updated: October 25, 2010

Page last updated: August 23, 2015

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