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Executive, Activities of Daily Living, and Cholinergic Functions in Parkinson's Disease

Information source: University of Michigan
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Parkinson's Disease

Intervention: Behavioral assessment/questionnaire (Behavioral)

Phase: N/A

Status: Completed

Sponsored by: University of Michigan


This research study will evaluate functions of memory, thinking, behavior, and daily life activities and how these relate to the measurement of certain chemicals (acetylcholine and dopamine) in the brain using an imaging procedure called positron emission tomography (PET). You may know that in Alzheimer's dementia (dementia is a disease where persons become forgetful and confused), a reduction in the amount of acetylcholine, a "neurotransmitter" substance (a chemical messenger that nerve cells need to communicate with each other), may be responsible for some of the memory and behavioral changes. At the present time, the investigators have no clear information on the levels of acetylcholine in the brain of patients with Parkinson's disease who also have memory or behavioral changes.

Clinical Details

Official title: Executive, Activities of Daily Living, and Cholinergic Functions in Parkinson's Disease

Study design: Observational Model: Case Control, Time Perspective: Prospective


Minimum age: 50 Years. Maximum age: 85 Years. Gender(s): Both.


Inclusion Criteria:

- PDD: Patients who meet the UK Parkinson's Disease Society Brain Bank Research Center

(UKPDSBRC) clinical diagnostic criteria for PD with dementia (MMSE 18-25; n=28; age 50-85 years; M/F) are eligible for the study. Hoehn and Yahr stages I-III.

- PD. Patients with who meet the UKPDSBRC criteria for PD with a MMSE of >25 (n=28; age

50-85 years; M/F). Hoehn and Yahr stages I-III.

- Normal control subjects (n=16) (age 50-85 years; M/F).

- No current or past history of neurologic or psychiatric illness.

Exclusion Criteria:

- Any subjects on cholinergic, anti-cholinergic drugs will be excluded from the study.

- Current or past history of neurologic or psychiatric illness.

Locations and Contacts

University of Michigan Functional, Cognitive and Mobility Laboratory, Ann Arbor, Michigan 48106, United States
Additional Information

Starting date: March 2006
Last updated: June 24, 2013

Page last updated: August 23, 2015

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