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Safety and Efficacy of Drug Combinations Against Triple Infections

Information source: DBL -Institute for Health Research and Development
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Parasitic Diseases

Intervention: albendazole + ivermectin + praziquantel (Drug); albendazole + ivermectin + (1 week later) praziquantel (Drug)

Phase: N/A

Status: Completed

Sponsored by: DBL -Institute for Health Research and Development


This randomised, controlled, double blinded clinical study investigates the safety and efficacy of the combination of albendazole, ivermectin and praziquantel in the treatment of children aged 5-18 years co-infected with lymphatic filariasis, schistosomiasis and soil-transmitted helminthiasis.

Clinical Details

Official title: Gaps in Helminth Control: Safety and Efficacy of Drug Combinations Against Triple Infections

Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Primary outcome: adverse reactions

Secondary outcome: Efficacy of treatment


Minimum age: 5 Years. Maximum age: 18 Years. Gender(s): Both.


Inclusion Criteria:

- Those who will be in class one to six by the time of study

- Aged 5-18 years and found infected with either SCH, any STH or LF for treatment

groups 1,2 or 3 or infected with both SCH and LF for treatment group 4 and infected with all the three for treatment group 5

- Who are willing and consent and whose parents will consent, will be included in the

study. Exclusion Criteria:

- Those with acute and chronic diseases other than the targeted infections and those

with a history of any serious adverse drug reactions will not be included in the study.

- Children with total bilirubin > 50┬Ámol/L and ALAT (Alanine transferase) > 70IU/L will

not qualify for recruitment.

Locations and Contacts

Vector Control Division, Kampala, Uganda
Additional Information

Starting date: October 2007
Last updated: January 14, 2010

Page last updated: August 23, 2015

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