The Effects of Preoperative Aspirin on Graft Patency and Cardiac Events in Off-pump Coronary Artery Bypass
Information source: Cardiovascular Institute & Fuwai Hospital
ClinicalTrials.gov processed this data on August 20, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Coronary Artery Disease; Off-pump Coronary Artery Bypass; Aspirin
Intervention: aspirin (Drug); aspirin (Drug)
Phase: Phase 3
Status: Recruiting
Sponsored by: Cardiovascular Institute & Fuwai Hospital
Summary
Antiplatelet therapy is critical in the management of coronary artery disease. For patients
undergoing off-pump coronary artery bypass graft,controversy remains regarding the safety of
preoperative antiplatelet therapy. And there is little study about the effect of continuing
aspirin until the surgery day on graft patency. So we would like to perform this study to
evaluate the effects of preoperative aspirin on graft patency and cardiac events in off-pump
coronary bypass.
Clinical Details
Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Primary outcome: graft patency examined by CT scan
Secondary outcome: Bleeding, transfusion, re-exploration
Eligibility
Minimum age: 18 Years.
Maximum age: 85 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Patients undergoing elective, off-pump coronary artery bypass with at least two
grafts
- patient able to give informed consent
Exclusion Criteria:
- on-pump CABG
- combined with the valve surgery
- Preoperative use of clopidogrel and warfarin
- allergy to aspirin
- History of severe liver disease
- History of bleeding diathesis,significant GI bleed
- Patient has known renal failure or contraindication for Cardiac CT Angio
- Redo CABG
Locations and Contacts
Fuwai Hospital, Beijing 100037, China; Recruiting Hengchao Wu, MD, Phone: 8601088398701, Email: whcwuhengchao@163.com Hansong Sun, MD, Principal Investigator
Additional Information
Starting date: March 2010
Last updated: December 30, 2010
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