DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more



The Effects of Preoperative Aspirin on Graft Patency and Cardiac Events in Off-pump Coronary Artery Bypass

Information source: Cardiovascular Institute & Fuwai Hospital
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Coronary Artery Disease; Off-pump Coronary Artery Bypass; Aspirin

Intervention: aspirin (Drug); aspirin (Drug)

Phase: Phase 3

Status: Recruiting

Sponsored by: Cardiovascular Institute & Fuwai Hospital

Summary

Antiplatelet therapy is critical in the management of coronary artery disease. For patients undergoing off-pump coronary artery bypass graft,controversy remains regarding the safety of preoperative antiplatelet therapy. And there is little study about the effect of continuing aspirin until the surgery day on graft patency. So we would like to perform this study to evaluate the effects of preoperative aspirin on graft patency and cardiac events in off-pump coronary bypass.

Clinical Details

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: graft patency examined by CT scan

Secondary outcome: Bleeding, transfusion, re-exploration

Eligibility

Minimum age: 18 Years. Maximum age: 85 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Patients undergoing elective, off-pump coronary artery bypass with at least two

grafts

- patient able to give informed consent

Exclusion Criteria:

- on-pump CABG

- combined with the valve surgery

- Preoperative use of clopidogrel and warfarin

- allergy to aspirin

- History of severe liver disease

- History of bleeding diathesis,significant GI bleed

- Patient has known renal failure or contraindication for Cardiac CT Angio

- Redo CABG

Locations and Contacts

Fuwai Hospital, Beijing 100037, China; Recruiting
Hengchao Wu, MD, Phone: 8601088398701, Email: whcwuhengchao@163.com
Hansong Sun, MD, Principal Investigator
Additional Information

Starting date: March 2010
Last updated: December 30, 2010

Page last updated: August 20, 2015

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017