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Effectiveness of Vancomycin Loading Therapy

Information source: Samsung Medical Center
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Infection

Intervention: Vancomycin HCL (Drug)

Phase: N/A

Status: Not yet recruiting

Sponsored by: Samsung Medical Center

Official(s) and/or principal investigator(s):
Kyong Ran Peck, MD, Principal Investigator, Affiliation: Samsung Medical Center

Overall contact:
Kyong Ran Peck, MD, Phone: +82-2-3410-0322, Email: krpeck@skku.edu

Summary

The goal of tish clinical research study is to identify that loading of vancomycin can faciliate rapid attainment of target trough serum vancomycin concentration.

Clinical Details

Official title: Effectiveness of Vancomycin Loading Therapy

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment

Primary outcome: Time duration for concentration of vancomycin to reach target trough of 15-20 mg/L

Secondary outcome: Adverse event rate in each arm, including nephrotoxicity and rash.

Detailed description: The Study drug

- Vancomycin : a glycopeptide antibiotic, is the first line agent in the treatment of

methicillin resistant stapylococcus aureus Study design : Randomized controlled trials Study Drug Administration

- If your doctor believes you are eligible, and you agree to take part in thish study,

you will be randomized to two treatment groups.

Eligibility

Minimum age: 20 Years. Maximum age: 75 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Admission to Samsung Medical Center MICU and general wards for infectious diseases

and hematology division

- Patients with SIRS (systemic inflammatory response syndrome)

- Intravenous vancomycin therapy deemed necessary

Exclusion Criteria:

- Age less than 20 years

- Age more than 75 years

- Current renal insufficiency defined as estimated Glomerular filtration rate <

50mg/min/1. 73 m2 by MDRD equation

- History of adverse events to vancomycin 5. Pregant woman

Locations and Contacts

Kyong Ran Peck, MD, Phone: +82-2-3410-0322, Email: krpeck@skku.edu

Samsung Medical Center, Seoul 135-710, Korea, Republic of; Not yet recruiting
Kyong Ran Peck, MD, Phone: +82-2-3410-0322, Email: krpeck@skku.edu
So Yeon Park, MD, Phone: +82-3410-0329, Email: miunori26@hanmail.net
Kyong Ran Peck, MD, Principal Investigator
So Yeon Park, MD, Sub-Investigator
Additional Information

Starting date: June 2012
Last updated: June 19, 2012

Page last updated: August 23, 2015

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