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Non- Essential Amino Acid Requirements and Metabolism in Humans

Information source: University of British Columbia
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Healthy Adult Males

Phase: N/A

Status: Completed

Sponsored by: University of British Columbia

Official(s) and/or principal investigator(s):
Rajavel Elango, Ph.D, Principal Investigator, Affiliation: University of British Columbia


Protein is a major structural component of all cells in the body. The nutritional importance of protein is because of their amino acids. 9 are called essential and 11 are called non-essential, based on whether we need to get them from diet. This classification is based on studies done using older techniques. Recent studies suggest that these so called non-essential amino acids play important roles in our body's health. For the first time, this proposal defines an experimental design to examine non- essential amino acid/nitrogen requirements and metabolism in humans using the Indicator Amino Acid Oxidation (IAAO) technique. The objective of the current study is to examine the application of IAAO technique to determine the non-essential amino acid/nitrogen requirement in adult humans.

Clinical Details

Official title: Application of Indicator Amino Acid Oxidation Technique to Determine Non-essential Amino Acids/Nitrogen Requirements in Adult Humans

Study design: Observational Model: Cohort, Time Perspective: Prospective

Primary outcome: 13 Carbon dioxide production


Minimum age: 20 Years. Maximum age: 40 Years. Gender(s): Male.


Inclusion Criteria:

- 20-40 years of age

- Male

- Classified as normal body weight based on body mass index (BMI) 18. 5-25kg/m2

- Free of any concurrent illness

Exclusion Criteria:

- Men not in good health or have a metabolic, neurological, genetic or immune disorder

including diabetes and hypertension

- Men who are classified as underweight(<18. 5kg/m2), overweight(25-30kg/m2) or obese

(>30kg/m2) using the BMI classification)

- Men who are allergic to milk, eggs and egg protein

Locations and Contacts

Child and Family Research Institute, Vancouver, British Columbia V5Z4H4, Canada
Additional Information

Starting date: October 2013
Last updated: May 29, 2015

Page last updated: August 23, 2015

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