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Comparison of the Efficacy and Safety of Ivermectin to Permethrin

Information source: University Ghent
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Scabies

Intervention: Administration of ivermectin or permethrin (Drug)

Phase: Phase 2

Status: Completed

Sponsored by: University Ghent

Official(s) and/or principal investigator(s):
Jean-Marie Naeyaert, MD, PhD, Principal Investigator, Affiliation: University Hospital, Ghent


Comparison of the efficacy and safety of a single administration of ivermectin to a single administration of permethrin for the treatment of scabies

Clinical Details

Official title: A Randomised, Double Blind, Double Dummy Study to Compare the Efficacy and Safety of a Single Administration of Ivermectin to a Single Administration of Permethrin for the Treatment of Scabies

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Primary outcome: Clinical healing of the skin injuries

Secondary outcome:

Decrease of itching

Amelioration of the life quality

Number and gravity of adverse events

Detailed description: Administration of ivermectin or permethrin on day0 Clinical examination and pictures on day0, day14 and day28 Blood sample on day0 VAS for pruritus, DLQI and SF-36 on day0, day14 and day28


Minimum age: 5 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria: At least one of the following inclusion criteria:

- Scabies tunnels

- Positive microscopic examination (acarids, faeces or ova)

At least two of the three following inclusion criteria:

- Non-specific injuries with a typical distribution pattern

- Serious itching which increases during the night

- Family or contacts with similar complaints

Exclusion Criteria:

- Treatment for scabies < 4 weeks ago

- Treatment with corticoids < 1 week ago

- Pregnancy

- Breast-feeding


- Serious immunodepressive patients

- Sensitivity or allergy to one of the components of the study medication

- Damage of the central nerve system

Locations and Contacts

University Hospital Ghent, Ghent 9000, Belgium
Additional Information

Website of the University Hospital Ghent

Starting date: July 2004
Last updated: December 19, 2007

Page last updated: August 23, 2015

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