Use of Erythromycin in Mustard-Induced Bronchiolitis
Information source: Baqiyatallah Medical Sciences University
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Bronchiolitis Obliterans; Acute Obliterating Bronchiolitis
Intervention: Erythromycin (Drug)
Phase: Phase 4
Status: Completed
Sponsored by: Baqiyatallah Medical Sciences University Official(s) and/or principal investigator(s): Mostafa Ghanei, Professor, Study Director, Affiliation: Research Center of Chemical Injuries, Baqyatallah Medical Sciences University, Tehran, Iran
Summary
We looked for the effectiveness of low-dose long-term prescription of erythromycin in
mustard-induced bronchiolitis obliterans
Clinical Details
Official title: Low-Dose Long-Term Prescription of Erythromycin in Mustard-Induced Bronchiolitis Obliterans
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double-Blind, Primary Purpose: Treatment
Eligibility
Minimum age: N/A.
Maximum age: N/A.
Gender(s): Male.
Criteria:
Inclusion Criteria:
- Documented chemical exposure
- Clinical, spirometric and radiological findings were compatible with BO on High
Resolution Computed Tomography (HRCT)
- Non-responsiveness to high dose bronchodilator therapy
Exclusion Criteria:
- Radiographic evidence of pneumonia, active tuberculosis, lung carcinoma, or an
infection that necessitated the use of an antibiotic
- History of cigarette smoking and occupational exposure to toxic agents of
hypersensitivity to macrolides
- History of treatment with a systemic antibiotic within 7 days before the start of the
study
- Any investigational medicine within 4 weeks of the study
- History of antibiotic injection within 6 weeks before the study
- Concomitant Theophylline or Carbamazepine, unless their serum concentrations were
regularly monitored
- Patients who were in the exacerbation phase of their respiratory complications
- Need to use medications interact with macrolides such as Digoxin, Theophylline and
Carbamazepine
- Systemic antibiotics
- Systemic Corticosteroids
- Admission to the hospital
- Abnormal kidney or liver function
Locations and Contacts
Baqiyatallah Medical Sciences University, Tehran 19945-546, Iran, Islamic Republic of
Additional Information
Last updated: November 4, 2008
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