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Investigating Systemic and Local Vascular Responses to Apelin in the Context of Renin-angiotensin Upregulation

Information source: University of Edinburgh
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Heart Disease; Heart Failure; Vasodilatation

Intervention: Apelin (Drug); Acetylcholine (Drug); Sodium nitroprusside (Drug); Systemic apelin infusion (Drug)

Phase: N/A

Status: Completed

Sponsored by: University of Edinburgh


The apelin-APJ system is a relatively new discovery. It has generated interest in part due to it's apparent ability to counteract the renin-angiotensin system, which is frequently overactive in many cardiovascular disease. Two of the main actions of apelin are to increase the pumping ability of the heart and cause blood vessels to relax. The investigators wish to assess if these actions are altered in the setting of normal renin-angiotensin activation and increased renin-angiotensin activity.

Clinical Details

Official title: Investigating the Interaction of Apelin and Systemic Angiotensin II Peripheral Resistance Vessels and Systemic Haemodynamics in Vivo in Man

Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Investigator), Primary Purpose: Basic Science

Primary outcome:

Change in cardiac output

Change in apelin mediated vasodilatation

Secondary outcome:

Change in systemic haemodynamics

Change in relevant neurohumoral hormones


Minimum age: 18 Months. Maximum age: 85 Years. Gender(s): Both.


Inclusion Criteria:

- >18yr

Exclusion Criteria:

- Lack of informed consent

- Age < 18 years,

- Current involvement in other research studies,

- Systolic blood pressure >190 mmHg or <100 mmHg

- Malignant arrhythmias

- Renal or hepatic failure

- Haemodynamically significant aortic stenosis

- Severe or significant co morbidity

- Women of childbearing potential.

- Any regular medication

- Previous history of any cardiovascular disease

Locations and Contacts

Clincial Research Facility, Royal Infirmary of Edinburgh, 51 Little France Cresc, Edinburgh EH16 4SA, United Kingdom
Additional Information

Starting date: April 2010
Last updated: August 9, 2010

Page last updated: August 23, 2015

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