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A Study to Assess Analgesic Efficacy of Intravenous Lignocaine

Information source: Jawaharlal Institute of Postgraduate Medical Education & Research
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Postoperative Pain; Postoperative Nausea and Vomiting; Postoperative Ileus

Intervention: Intravenous lignocaine (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: Jawaharlal Institute of Postgraduate Medical Education & Research

Official(s) and/or principal investigator(s):
parnandi sridhar, MBBS, Principal Investigator, Affiliation: Junior resident,JAWAHARLAL INSTITUTE OF POSTGRADUATE MEDICAL EDUCATION AND RESEARCH, PUDUCHERRY, INDIA

Summary

The primary objectives of this study are to analyse the effect of perioperative systemic infusion of lignocaine on postoperative pain, postoperative nausea and vomiting and perioperative levels of inflammatory mediators in patients undergoing elective open abdominal surgeries. The secondary parameters which will be observed during the study are the time to passage of flatus and stools postoperatively.

Clinical Details

Official title: Effect of Perioperative Systemic Lignocaine on Postoperative Pain in Patients Undergoing Elective Open Abdominal Surgeries- a Double Blinded Randomized Control Trial

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Primary outcome: postoperative pain scores using visual analogue scale

Secondary outcome:

Number of patient controlled analgesia demands

Total amount of morphine consumed

Detailed description: Patients will be randomized into two groups- A and B, to receive an intravenous infusion of lignocaine or saline,respectively, as a bolus of 1. 5mg/kg at the time of intubation followed by an infusion at a rate of 1. 5mg/kg/hr continued throughout the surgery and till one hour postop. Postoperative analgesia will be provided through Patient Controlled Analgesia (PCA) pump providing morphine. Postoperative pain scores will be noted at immediate postoperative and at 6, 18, 24 hours post surgery. The number of PCA demands and cumulative morphine consumption till 24 hours post surgery will be noted. The incidence of postoperative nausea and vomiting is recorded. The time to first passage of flatus and stools postoperatively will be noted. Levels of total leukocyte count, c-reactive protein (CRP) and interleukin-6(IL-6) will be noted in preoperative, immediate post operative and 24 hours post surgery.

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- patients above 18 years of age

- undergoing elective open abdominal surgeries

- belonging to the American Society of Anaesthesiologists (ASA)status I,II,III

Exclusion Criteria:

- patients sensitive to lignocaine,

- patients suffering from cardiovascular diseases or with preoperative changes on

electrocardiogram

- patients on beta blocker drugs

- patients on opioid drugs for prolonged period

- patients with functional bowel disorders

Locations and Contacts

Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry 605006, India
Additional Information

Related publications:

Cassuto J, Wallin G, Högström S, Faxén A, Rimbäck G. Inhibition of postoperative pain by continuous low-dose intravenous infusion of lidocaine. Anesth Analg. 1985 Oct;64(10):971-4.

Groudine SB, Fisher HA, Kaufman RP Jr, Patel MK, Wilkins LJ, Mehta SA, Lumb PD. Intravenous lidocaine speeds the return of bowel function, decreases postoperative pain, and shortens hospital stay in patients undergoing radical retropubic prostatectomy. Anesth Analg. 1998 Feb;86(2):235-9.

Starting date: April 2011
Last updated: October 3, 2012

Page last updated: August 23, 2015

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