DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more



The Efficacy of Topical Minocycline in Managing Symptomatic Oral Lichen Planus

Information source: Sheba Medical Center
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Oral Lichen Planus

Intervention: Minocycline (Drug); Dexamethasone (Drug)

Phase: Phase 3

Status: Not yet recruiting

Sponsored by: Sheba Medical Center

Official(s) and/or principal investigator(s):
Noam Yarom, DMD, Principal Investigator, Affiliation: Sheba Medical Center

Overall contact:
Noam Yarom, DMD, Phone: +972-3-5303819, Email: noamyar@post.tau.ac.il

Summary

The aim of the present study is to assess the clinical efficacy of topical minocyclin in managing of symptoms associated with oral lichen planus (OLP). The rationale of the study is based on our previous studies demonstrating the beneficial effect of minocyclin mouthwash on recurrent aphthous stomatitis. The planned study will be a randomized controlled, cross-over trail. Patients with symptomatic OLP will randomly receive minocycline or dexamethasone rinses. The patients will rinse and expectorate 5 ml of the 1st mouthwash 4 times daily for 14 days. Subjects will complete a daily follow-up form that includes data regarding the daily intensity of pain (using VAS) caused by OLP and regarding possible side effects. After a washout period (at least 14 days) the patients will repeat the protocol with the second mouthwash.

Clinical Details

Official title: The Efficacy of Topical Minocycline in Managing Symptomatic Oral Lichen Planus. A Randomized Controlled Trial

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Primary outcome: symptoms relief

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- OLP patients (Biopsy proven)

Exclusion Criteria:

- Known allergy to Dexamethasone or Minocycline

- Pregnancy

Locations and Contacts

Noam Yarom, DMD, Phone: +972-3-5303819, Email: noamyar@post.tau.ac.il

Additional Information

Starting date: March 2010
Last updated: March 8, 2010

Page last updated: August 23, 2015

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017