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Effect of Ketamine Addition to Lidocaine in Rhinoplasty

Information source: Inonu University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Nose Deformities, Acquired

Intervention: Lidocaine 2 % (Drug); Ketamine plus Lidocaine (Drug); Saline (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: Inonu University

Official(s) and/or principal investigator(s):
Mukadder Sanli, MD, Principal Investigator, Affiliation: Turgut Ozal Medical Center


The purpose of this study is to determine whether subanesthetic ketamine addition to lidocaine decreases postoperative pain scores in infiltration anesthesia during rhinoplasty.

Clinical Details

Official title: Effect of Ketamine Addition to Lidocaine for Postoperative Pain Management in Rhinoplasty

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: Postoperative pain scores on the Visual Analogue Scale

Secondary outcome:

Patient satisfaction

Analgesic demand

Detailed description: In rhinoplasty operations local infiltration anesthesia uses for surgery insight and patient comfort. The investigators designed this study to prolonged the time of infiltration block and preventive analgesia. So, before operation, study drugs will infiltrate to the submucosa of intranasal cavity. Then, surgeon and patient satisfaction, postoperative analgesic demand, postoperative pain scores and side effects will determine.


Minimum age: 18 Years. Maximum age: 50 Years. Gender(s): Both.


Inclusion Criteria:

- Patients scheduled for elective rhinoplasty operation under general anesthesia

- Patients with ASA (American Society of Anesthesiology) class I

- Patients between 18-50 years old

Exclusion Criteria:

- Age <18 and >50

- ASA > II

- Preexisting neurological or psychiatric illness

- Systemic diseases (diabetes mellitus, hypertension, coronary heart disease...)

- Having a history of chronic pain and receiving chronic analgesia therapy

- Having a history of drug abuse

Locations and Contacts

Turgut Ozal Medical Center, Malatya 44315, Turkey
Additional Information

Starting date: January 2013
Last updated: April 8, 2013

Page last updated: August 23, 2015

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