Countermeasures to Reduce Sensorimotor Impairment and Space Motion Sickness Resulting From Altered Gravity Levels
Information source: Schepens Eye Research Institute
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Vestibular
Intervention: Promethazine (Drug); Hyper gravity training (Behavioral); Placebo (Drug); No hypergravity training (Behavioral)
Phase: Phase 4
Status: Not yet recruiting
Sponsored by: Faisal Karmali Official(s) and/or principal investigator(s):
Faisal Karmali, Ph.D., Principal Investigator, Affiliation: Massachusetts Eye and Ear Infirmary
Overall contact:
Faisal Karmali, Ph.D., Phone: 617-573-5593, Email: faisal_karmali@meei.harvard.edu
Summary
Adaptation to altered gravity has been of concern from the earliest reports of space motion
sickness, through the Apollo exploration era, and into current planning of exploration
missions. The proposed research program takes a new approach which could lead to an
effective, practical and acceptable protocol for preadapting astronauts to space flight. By
using the gravito-inertial alterations possible with centrifugation in different body
orientations the investigators will quantify an individual's sensory adaptation capability
and use it to predict and to minimize the consequences of movement in any other gravity
environment - eventually including weightlessness. The investigators will also study whether
a drug (promethazine) affects motion perception and motion sickness.
Clinical Details
Official title: Countermeasures to Reduce Sensorimotor Impairment and Space Motion Sickness Resulting From Altered Gravity Levels
Study design: Allocation: Randomized, Intervention Model: Factorial Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science
Primary outcome: Rate of recovery of roll tilt perception errors after exposure to hypergravity
Eligibility
Minimum age: 18 Years.
Maximum age: 45 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Subjects must be in general good health
Exclusion Criteria:
- Anyone who is not generally in good general health does not qualify
- Cardiovascular disease
- Severe diabetes
- Respiratory condition (e. g. asthma or emphysema)
- Narrow angle glaucoma
- Prostatic hypertrophy
- Gastrointestinal disorders
Locations and Contacts
Faisal Karmali, Ph.D., Phone: 617-573-5593, Email: faisal_karmali@meei.harvard.edu
Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, United States; Not yet recruiting
Additional Information
Starting date: June 2014
Last updated: May 8, 2014
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