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Effectiveness of Oral Acetazolamide, Brimonidine Tartarate, and Anterior Chamber Paracentesis in Intraocular Pressure (IOP) After Bevacizumab

Information source: University of Sao Paulo
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Macular Edema; Diabetic Retinopathy; Macular Degeneration

Intervention: bevacizumab (Drug); anterior chamber paracentesis (Procedure); acetazolamide (Drug); brimonidine (Drug)

Phase: Phase 2

Status: Completed

Sponsored by: University of Sao Paulo


Purpose: To evaluate the effects of anterior chamber paracentesis, brimonidine and oral acetazolamide to reduce intra-ocular pressure (IOP) variations after intravitreal bevacizumab injection (IVBV). Methods: 47 patients scheduled for IVBV (1. 5 mg / 0. 06 ml) will be randomly assigned to a pre-treatment 1 hour before IVBV with either 250 mg oral acetazolamide (DIA, 9 eyes), anterior chamber paracentesis immediate after IVBV (PAR, 15 eyes), topic brimonidine tartarate 1 hour before IVBV (BRI, 14 eyes), or no pre-treatment IBVB (CTR, 9 eyes). IOP will be measured 90 minutes before injection (baseline), just before injection, and at 3, 10, 20 and 30 minutes after the procedure.

Clinical Details

Official title: Effectiveness of Oral Acetazolamide, Brimonidine Tartarate, and Anterior Chamber Paracentesis for Ocular Hypertension Control After Intravitreal Bevacizumab Injection: Preliminary Results

Study design: N/A

Primary outcome: Intra-ocular pressure variation after intra-vitreous injection of bevacizumab


Minimum age: 50 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- macular edema

Exclusion Criteria:

- pulmonary chronic problems

- chronic renal failure

- intraocular inflammation

- drug or alcohol addiction

Locations and Contacts

School of Medicine - Clinical Hospital, Ribeirao Preto, SP 14049-900, Brazil
Additional Information

Last updated: December 8, 2008

Page last updated: August 20, 2015

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