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Influence of Losartan and Diphenhydramine on Emotional and Cognitive Functions in Healthy Human Subjects

Information source: University of Basel
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Memory, Long-Term; Memory, Short-Term

Intervention: Losartan, Diphenhydramine, Placebo (Drug)

Phase: N/A

Status: Completed

Sponsored by: Prof. Dominique de Quervain, MD

Official(s) and/or principal investigator(s):
Dominique de Quervain, Prof. MD, Principal Investigator, Affiliation: University of Basel, Faculty of Psychology and Medecine, Division of Cognitive Neuroscience


This project aims at identifying novel pharmacological targets for the treatment of memory disorders.

Clinical Details

Official title: Influence of Losartan and Diphenhydramine on Emotional and Cognitive Functions in Healthy Human Subjects

Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Basic Science

Primary outcome: Primary Outcome Measures

Secondary outcome: Secondary Outcome Measures

Detailed description: To investigate the effects of the histamine H1 receptor antagonist diphenhydramine and the angiotensin II receptor antagonist losartan on emotional and cognitive functions in healthy human subjects.


Minimum age: 18 Years. Maximum age: 40 Years. Gender(s): Both.


Inclusion Criteria:

- healthy

- native or fluent German-speaking

- BMI between 19 and 27 kg/m2

- able and willing to give written informed consent and comply with the requirements of

the study protocol

- willing to donate saliva sample for DNA-analysis

- female: willing to perform a pregnancy test at the beginning of both test visits

Exclusion Criteria:

- acute or chronic psychiatric or somatic disorder

- pathological ECG

- known hypersensitivity to the IMP under investigation (losartan, diphenhydramine)

- hypotension (RR < 110/70 mmHg)

- bradycardia (< 50 bpm)

- pregnancy, breast-feeding

- long-term medication within last 3 months (oral contraceptives are disregarded)

- smoking (> 3 cigarettes per day)

- concurrent participation in another study

- participation in one of our previous studies using the same memory tests

- inability to read and understand the participant's information

Locations and Contacts

University of Basel, Division of Cognitive Neuroscience, Basel 4055, Switzerland
Additional Information

Starting date: March 2011
Last updated: May 2, 2012

Page last updated: August 23, 2015

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