Influence of Losartan and Diphenhydramine on Emotional and Cognitive Functions in Healthy Human Subjects
Information source: University of Basel
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Memory, Long-Term; Memory, Short-Term
Intervention: Losartan, Diphenhydramine, Placebo (Drug)
Phase: N/A
Status: Completed
Sponsored by: Prof. Dominique de Quervain, MD Official(s) and/or principal investigator(s):
Dominique de Quervain, Prof. MD, Principal Investigator, Affiliation: University of Basel, Faculty of Psychology and Medecine, Division of Cognitive Neuroscience
Summary
This project aims at identifying novel pharmacological targets for the treatment of memory
disorders.
Clinical Details
Official title: Influence of Losartan and Diphenhydramine on Emotional and Cognitive Functions in Healthy Human Subjects
Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Basic Science
Primary outcome: Primary Outcome Measures
Secondary outcome: Secondary Outcome Measures
Detailed description:
To investigate the effects of the histamine H1 receptor antagonist diphenhydramine and the
angiotensin II receptor antagonist losartan on emotional and cognitive functions in healthy
human subjects.
Eligibility
Minimum age: 18 Years.
Maximum age: 40 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- healthy
- native or fluent German-speaking
- BMI between 19 and 27 kg/m2
- able and willing to give written informed consent and comply with the requirements of
the study protocol
- willing to donate saliva sample for DNA-analysis
- female: willing to perform a pregnancy test at the beginning of both test visits
Exclusion Criteria:
- acute or chronic psychiatric or somatic disorder
- pathological ECG
- known hypersensitivity to the IMP under investigation (losartan, diphenhydramine)
- hypotension (RR < 110/70 mmHg)
- bradycardia (< 50 bpm)
- pregnancy, breast-feeding
- long-term medication within last 3 months (oral contraceptives are disregarded)
- smoking (> 3 cigarettes per day)
- concurrent participation in another study
- participation in one of our previous studies using the same memory tests
- inability to read and understand the participant's information
Locations and Contacts
University of Basel, Division of Cognitive Neuroscience, Basel 4055, Switzerland
Additional Information
Starting date: March 2011
Last updated: May 2, 2012
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