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Effect of Betamethasone Gel and Lidocaine Jelly on Sore Throat, Cough and Hoarseness of

Information source: Tehran University of Medical Sciences
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Sore Throat; Cough

Intervention: betamethasone gel (Drug); lidocaine jelly (Drug); distilled water (Drug)

Phase: Phase 3

Status: Completed

Sponsored by: Tehran University of Medical Sciences


ABSTRACT: The aim of this study was to investigate the effect of betamethasone gel and lidocaine jelly (over tracheal tube cuff) compared with distilled water on the post intubation syndrome incidence. This study has not been carried out in Iran. 99 patients of either sex undergoing elective surgery were recruited in a single blind randomized study. The patients, using randomization table, were divided into three groups. Anesthetics and medications used during surgery were similar for all the patients. For the all patients, the incidence of postoperative sore throat, cough and hoarseness of the voice in the different follow-up periods (1, 6 and 24 hours) based on the different types of medications were obtained.

Clinical Details

Official title: Effect of Betamethasone Gel and Lidocaine Jelly Applied Over Tracheal Tube Cuff on Post Operative Sore Throat, Cough and Hoarseness of Voice on the Patients

Study design: Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Caregiver), Primary Purpose: Treatment

Primary outcome:

sore throat


hoarseness of voice

sore throat

sore throat



hoarseness of voice

hoarseness of voice


Minimum age: 15 Years. Maximum age: 50 Years. Gender(s): Both.


Inclusion Criteria: 1. 50 years15 years 2. no acute upper respiratory infections and no sore throat 3. candidate for elective surgery unrelated to the throat 4. The lack of airways difficulties 5. candidate for general anesthesia with intubation 6. no contraindications for receiving steroid 7. surgery time < 240 minutes 8. intubation up to 2 times 9. tracheal tube cuff pressure = 25-30 cm H2o 10. fasting for 8-6 hours prior to surgery 11. ASA I and ASAII and 12. Surgery under general anesthesia and endotracheal intubation Exclusion Criteria: 1. use of nasogastric tube or throat packs 2. patients with upper respiratory tract infection 3. patients on steroid therapy were excluded from the study

Locations and Contacts

Department of Anesthesiology, Booali Hospital, Islamic Azad University,, Tehran, Iran, Islamic Republic of
Additional Information

Starting date: March 2012
Last updated: April 14, 2014

Page last updated: August 23, 2015

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