Clarithromycin is an Adjunct to Scaling and Root Planing
Information source: Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Periodontitis
Intervention: tablet clarithromycin 500 mg (Clarino-500) orally (Drug)
Phase: Phase 4
Status: Completed
Sponsored by: Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Summary
The present study was done to evaluate the effect of clarithromycin as an adjunct to scaling
and root planning at baseline, three months and six months intervals . Clinical,
microbiological and immunological parameters were taken. Clinical parameters include
gingival index , probing depth and clinical attachment level. In the present study,
improved clinical and microbiological outcomes were attained using adjunctive
clarithromycin, including GI, PD reduction, CAL gain and reductions in the frequency of
detection of C-reactive protein, Pg, Aa. These results together with the recommended easy
dosage and limited side effects make the use of this antibiotic in the treatment of
periodontitis patients but only for a shorter period of time.
Clinical Details
Official title: Efficacy of Clarithromycin is an Adjunct to Scaling and Root Planing .A Clinical Microbiological and Immunological Study.
Study design: Allocation: Non-Randomized, Endpoint Classification: Bio-availability Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Supportive Care
Primary outcome: Efficacy of Clarithromycin, as measured by reduction Gingival bleedingEfficacy of Clarithromycin, as measured by Pocket probing depth Efficacy of Clarithromycin, as measured by Clinical attachment gain c-reactive protein levels Pg and Aa bacterial count
Detailed description:
Background & Objectives: Along with conventional non-surgical periodontal therapy (NSPT)
systemic antimicrobials may provide more effective treatment for chronic periodontitis by
targeting tissue-invasive bacteria. The aim of this study was to evaluate the adjunctive
effects of oral clarithromycin (CLM) to nonsurgical periodontal therapy for chronic
periodontitis.
Materials and Methods: 30 patients were categorized into two groups: test group - Base line
scaling and root planing(SRP) was done. Clarithromycin tablet 500 mg( Clarino-500) was given
for a period of 7 days orally two times per day. control group - only SRP done . Clinical
parameters were recorded at baseline , 3 months, and six months interval .They included
gingival index (GI), probing depth (PD), and clinical attachment level (CAL). Also microbial
analysis of subgingival plaque samples was done at baseline, 3months and six months
interval to estimate the levels of Pg and Aa bacteria using culture methods. Immunological
parameter like estimation of C-Reactive protein was done in both groups at baseline 3 months
and 6 months period. tests were used for statistical analysis.
Eligibility
Minimum age: 30 Years.
Maximum age: 50 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Patients age ranged between 30- 50 years with chronic periodontitis
- Patients with Probing Depth (PD)- >5mm, Clinical Attachment Level( CAL)- >3mm
- Systemically healthy individuals
Exclusion Criteria:
- Patients below the age of 30 years
- Patients who have undergone periodontal therapy 3 months prior to study
- Active /passive smokers
- Any antibiotic use 3 months prior to study
- Pregnant women and lactating mothers
- Un co- operative/ retarded patients
- Drug allergy/ other allergies
- Any systemic diseases
Locations and Contacts
Additional Information
Related publications: Kathariya R, Pradeep AR, Raghavendra NM, Gaikwad R. Evaluation of subgingivally delivered 0.5% clarithromycin as an adjunct to nonsurgical mechanotherapy in the management of chronic periodontitis: a short-term double blinded randomized control trial. J Investig Clin Dent. 2014 Feb;5(1):23-31. doi: 10.1111/jicd.12009. Epub 2012 Oct 25. Bajaj P, Pradeep AR, Agarwal E, Kumari M, Naik SB. Locally delivered 0.5% clarithromycin, as an adjunct to nonsurgical treatment in chronic periodontitis with well-controlled type 2 diabetes: a randomized controlled clinical trial. J Investig Clin Dent. 2012 Nov;3(4):276-83. doi: 10.1111/j.2041-1626.2012.00168.x. Epub 2012 Sep 13. Agarwal E, Pradeep AR, Bajaj P, Naik SB. Efficacy of local drug delivery of 0.5% clarithromycin gel as an adjunct to non-surgical periodontal therapy in the treatment of current smokers with chronic periodontitis: a randomized controlled clinical trial. J Periodontol. 2012 Sep;83(9):1155-63. doi: 10.1902/jop.2012.110600. Epub 2012 Jan 16.
Starting date: January 2012
Last updated: February 4, 2015
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