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Comparative Pain Control Between 0.2 or 0.3 Spinal Morphine and 0.25 or 0.5 % Bupivacaine for FNB After TKA

Information source: Mahidol University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Post Operative Pain; Total Knee Replacement

Intervention: morphine and bupivacaine (Drug); spinal morphine and marcaine (Drug); morphine and bupivacaine (Drug); morphine and bupivacaine (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: Mahidol University

Official(s) and/or principal investigator(s):
Thitima Chinachoti, MD, Principal Investigator, Affiliation: Siriraj Hospital


Comparative efficacy of 24 and 48 hours post operative pain control in single total knee replacement between intrathecal bupivacaine with 0. 2 or 0. 3 mg morphine together with 0. 25 or 0. 5 % bupivacaine for single femoral nerve block

Clinical Details

Official title: Comparative Effect of 0.2 or 0.3 Spinal Morphine and 0.25 or 0.5 % Bupivacaine for Femoral Nerve Block After Total Knee Replacement

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: Global assessment in post operative pain control

Secondary outcome: Global assessment of post operative pain in 48 HOURS AND SIDE EFFECTS


Minimum age: 45 Years. Maximum age: 75 Years. Gender(s): Both.


Inclusion Criteria:

- Single elective total knee replacement in ASA 1-3 without significant cardiovascular

limitation Exclusion Criteria:

- patient at risk in usage COX-2 for post operative pain control

Locations and Contacts

Siriraj Hospital, Bangkok, Bangkoknoi 10700, Thailand
Additional Information

Starting date: October 2008
Last updated: September 28, 2009

Page last updated: August 23, 2015

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