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Does Thiamine Help Vomiting and Nausea in Pregnancy?

Information source: HaEmek Medical Center, Israel
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Hyperemesis Gravidarum

Intervention: thiamine & promethazine (Drug)

Phase: Phase 3

Status: Terminated

Sponsored by: HaEmek Medical Center, Israel

Official(s) and/or principal investigator(s):
Yfat Kadan, Principal Investigator, Affiliation: haemek medical center


There are different treatments for nausea and vomiting in pregnancy. According to the ACOG recommendations, promethazine is the first line of parenteral treatment after oral treatment had failed. Thiamine is given to prevent wernicke encephalopathy. This research try to find out whether thiamine helps the vomiting and nausea as well, by comparing the response to thiamine and promethazine in women who suffer from nausea and vomiting in pregnancy.

Clinical Details

Official title: Comparison Between the Treatment of Thiamine and Promethazine for Improving Vomiting and Nausea in Pregnancy

Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: the improvement in nausea and/or vomiting after treatment

Detailed description:

- Research groups: pregnant women eho visit the emergency room for nausea and vomiting in

pregnancy, pregnancy age 12 weeks or less

- After basic examinations and hydration, the women will randomized to thiamine or

promethazine treatment.

- If no improvement is shown, the patient will be treated with the other drug

- The patients will be interviewed on their current visit and every two weeks until 14th

week of gestation

- The interview includes medical history and details about their illness, other

treatments, hospitalization etc.


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Female.


Inclusion Criteria:

- Pregnant women until 12th week of gestation

- The women visit the ER because of nausea and vomiting

- The women didn't received thiamine yet

Exclusion Criteria:

- Pregnant women over 12th week of gestation

- Women that received thiamine before

- women that allergic to the studied drugs

Locations and Contacts

Gynecologic department, Haemek medical center, Afula, Israel
Additional Information

Starting date: February 2009
Last updated: June 21, 2015

Page last updated: August 23, 2015

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