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Effects of Prednisolone and Infliximab on the Regulation of Urea Synthesis in Active Inflammatory Bowel Disease

Information source: University of Aarhus
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Inflammatory Bowel Diseases

Phase: N/A

Status: Completed

Sponsored by: University of Aarhus

Official(s) and/or principal investigator(s):
Karen Louise Thomsen, MD, Principal Investigator, Affiliation: Aarhus University Hospital

Summary

Loss of total mass of muscles (catabolism) is a serious clinical problem in patients with active inflammatory bowel disease (IBD). The investigators have earlier shown that the liver plays an important role in this stress-catabolism by increasing the production of urea during the inflammatory process. The purpose of this study is to examine the effect of the anti-inflammatory drugs prednisolone and infliximab on the regulation of the urea synthesis in patients with active ulcerative colitis and Crohn's disease.

Clinical Details

Official title: Effects of Prednisolone and Infliximab on the Regulation of Urea Synthesis in Patients With Active Ulcerative Colitis and Crohn's Disease

Study design: Observational Model: Case-Crossover, Time Perspective: Prospective

Primary outcome: Functional Hepatic Nitrogen Clearance

Secondary outcome: Clinical and biochemical measures of inflammation

Eligibility

Minimum age: 18 Years. Maximum age: 50 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Moderate to severe active inflammatory bowel disease

Exclusion Criteria:

- Viral or bacterial infections

- Other chronical inflammatory diseases

- Cancer

- Other catabolic diseases

- Treatment with prednisolone or infliximab within the last 8 weeks

Locations and Contacts

Department of Medicine V, Aarhus University Hospital, Aarhus 8000, Denmark
Additional Information

Starting date: January 2009
Last updated: October 11, 2012

Page last updated: August 23, 2015

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