Pharmacokinetic Interactions of Losartan and Hydrochlorothiazide
Information source: Damanhour University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Healthy Normotensive Participants
Intervention: Losartan/hydrochlorothiazide (Drug); Losartan (Drug); Hydrochlorothiazide (Drug)
Phase: N/A
Status: Completed
Sponsored by: Damanhour University
Summary
This study was conducted to investigate any potential reaction between losartan and
hydrochlorothiazide.
Clinical Details
Study design: Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Crossover Assignment, Masking: Open Label
Primary outcome: Heart rateBlood pressure Pharmacokinetic parameter such as Cmax of losartan and hydrochlorothiazide Pharmacokinetic parameter such as AUC of losartan and hydrochlorothiazide
Eligibility
Minimum age: 18 Years.
Maximum age: 45 Years.
Gender(s): Male.
Criteria:
Inclusion Criteria:
- At least 18 years old and not more than 45 healthy male volunteers
- Who had passed all the screening parameters
Exclusion Criteria:
- A clinically significant abnormal physical exam, medical history, or laboratory
studies
- If they showed a sitting SBP of >140 or <100 mmHg, DBP > 90 or <60mm Hg, or a pulse
rate of > 95 or < 50 beats/min at screening
- The use of any prescription drug within the previous month or use of any
over-the-counter medication within the past 14 days
- A history of blood dyscrasias
- A history of alcohol or drug abuse within the past year
- Donation of blood during the 8 weeks prior to the study or plans to donate blood
during or within 8 weeks of completing the study
- Unable to tolerate vein puncture and multiple blood samplings
- Any surgical/medical condition that might alter drug absorption, distribution,
metabolism, or excretion
Locations and Contacts
Additional Information
Starting date: February 2013
Last updated: May 24, 2013
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