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Mechanisms of Human Cutaneous Microcirculation in Healthy Volunteers

Information source: University Hospital, Angers
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Healthy Volunteers

Intervention: pressure strain system, iontophoresis (Device); scopolamin (Drug); emla (Drug); capsaicin (Drug); aspirin (Drug); clopidogrel (Drug); celecoxib (Drug); indomethacin (Drug); acetylcholine (Drug); sodium nitroprusside (Drug); brethyllium (Drug); general and local heating (Device)

Phase: Phase 4

Status: Recruiting

Sponsored by: University Hospital, Angers

Official(s) and/or principal investigator(s):
Jean Louis SAUMET, MD - PhD, Principal Investigator, Affiliation: University Hospital, Angers

Overall contact:
Pierre ABRAHAM, MD, PhD, Phone: (0)2-41-35-46-17, Ext: 33, Email: piabraham@chu-angers.fr


Microvascular dysfunctions are critical events in several diseases including diabetes. This study will develop a methodology for microvascular investigation in human skin. The purpose of the study is to investigate the physiological response of the cutaneous microcirculation to physical, thermal, mechanical or chemical stimulations.

Clinical Details

Official title: Etude de la Reserve Vasomotrice Microcirculatoire cutanée

Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Diagnostic

Primary outcome: Amplitude of the vasomotor response to stimuli

Secondary outcome: Kinetics of the vasomotor response to stimuli

Detailed description: This study has investigated various aspects of the physiology of the microcirculation in the past years and is still recruiting under parallel protocols of physiological investigations of the neurovascular control of the cutaneous microcirculation.


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- Healthy volunteers with no clinical signs of, or risk factors for, vascular disease

Exclusion Criteria:

- Smokers, Pregnancy, Allergy,

Locations and Contacts

Pierre ABRAHAM, MD, PhD, Phone: (0)2-41-35-46-17, Ext: 33, Email: piabraham@chu-angers.fr

Laboratoire de Physiologie et Explorations Vasculaires - CHU Angers, Angers 49033, France; Recruiting
Pierre ABRAHAM, MD, PhD, Phone: (0)2-41-35-46-17, Ext: 33, Email: piabraham@chu-angers.fr
Additional Information

Starting date: January 1996
Last updated: March 16, 2007

Page last updated: August 23, 2015

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