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Comparison of Intravitreal Bevacizumab and Triamcinolone With Placebo

Information source: Shahid Beheshti Medical University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Acute Nonarteritic Anterior Ischemic Optic Neuropathy

Intervention: Avastin and Triamcinolone (Drug); placebo (Other)

Phase: Phase 1/Phase 2

Status: Recruiting

Sponsored by: Shahid Beheshti Medical University

Summary

In this study 16 Patients diagnosed with Nonarteritic Anterior Ischemic Optic Neuropathy(NSION) who had a sudden mono ocular vision loss associated with optic disc edema and positive Marcus Gunn in less than 30 days without exclusion criteria are randomly divided in two groups 1) control 2) case. In case group Avastin and Triamcinolone will be injected trough vitreal and placebo will be injected in control group. BCVA and Visual field will be then measured in these two groups.

Clinical Details

Official title: Comparison of Intravitreal Bevacizumab and Triamcinolone With Placebo in Acute Nonarteritic Anterior Ischemic Optic Neuropathy

Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: Changes of Best corrected visual acuity(BCVA)

Secondary outcome: Changes of Visual Field

Eligibility

Minimum age: N/A. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion criteria:

- Sudden mono ocular vision loss associated with optic disc edema and positive Marcus

Gunn (<30 days) Exclusion criteria:

- Any eye disease except NAION(Nonarteritic Anterior Ischemic Optic Neuropathy)

- Neurologic defect

- Abnormal ESR, CRP, any history of retina or vitreal surgery

- Severe corneal opacity which makes retina examination impossible

Locations and Contacts

Labbafinejad medical center, Tehran, Iran, Islamic Republic of; Recruiting
morteza entezari, Associate Professor, Phone: 00982122585952, Email: entmort@hotmail.com
morteza entezari, associat of profesor, Principal Investigator
Additional Information

Starting date: January 2010
Last updated: April 5, 2011

Page last updated: August 23, 2015

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