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The Lipid Profile of the Skin Surface in Acne

Information source: University of California, Davis
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Acne

Intervention: Tretinoin or Adapalene (Drug); Isotretinoin (Drug)

Phase: N/A

Status: Active, not recruiting

Sponsored by: University of California, Davis

Official(s) and/or principal investigator(s):
Raja K Sivamani, MD, Principal Investigator, Affiliation: UC Davis


The purpose of this study is to evaluate the differences in the skin lipid profile of patients with and without acne. Secondly, the goal is to learn more about what the effects of retinoinds (topical and systemic) are on the the skin lipid profile. We hypothesize that the skin lipid profile of subjects with acne will be lower in inflammatory lipids in comparison to subjects without acne.

Clinical Details

Official title: The Lipid Profile of the Skin Surface in Acne

Study design: Observational Model: Case Control, Time Perspective: Prospective

Primary outcome: Skin lipid profile of acne and healthy patients

Secondary outcome: Skin lipid profile of acne patients after treatment

Detailed description: Skin lipid profile will be conducted via sebutapes- adhesive tapes that painlessly absorbs sebum from the face. These tapes will be placed on the face for 1 hour. A photograph of the face will be taken during each study visit. A sebumeter will also be used to measure skin sebum secretion rate.


Minimum age: 12 Years. Maximum age: 30 Years. Gender(s): Both.


Inclusion Criteria:

- age 12 to 30 years

- have been prescribed tretinoin OR isotretinoin

Exclusion Criteria:

- those who have taken isotretinoin (systemic)

- those who used tretinoin or other topical retinoid within two weeks of starting the


- those with seborrheic dermatitis, rosacea, or polycystic ovary syndrome

- those who are pregnant, prisoners, or cognitively impaired

- those who do not fit the inclusion criteria

Locations and Contacts

Dermatology Research Area, Davis, California 95616, United States

UC Davis Department of Dermatology, Sacramento, California 95816, United States

Additional Information

University of California-Davis Department of Dermatology Clinical Research

Related publications:

Thody AJ, Shuster S. Control and function of sebaceous glands. Physiol Rev. 1989 Apr;69(2):383-416. Review.

Blume U, Verschoore M, Poncet M, Czernielewski J, Orfanos CE, Schaefer H. The vellus hair follicle in acne: hair growth and sebum excretion. Br J Dermatol. 1993 Jul;129(1):23-7.

Zouboulis CC, Baron JM, Böhm M, Kippenberger S, Kurzen H, Reichrath J, Thielitz A. Frontiers in sebaceous gland biology and pathology. Exp Dermatol. 2008 Jun;17(6):542-51. doi: 10.1111/j.1600-0625.2008.00725.x. Review.

Doshi A, Zaheer A, Stiller MJ. A comparison of current acne grading systems and proposal of a novel system. Int J Dermatol. 1997 Jun;36(6):416-8.

Morello AM, Downing DT, Strauss JS. Octadecadienoic acids in the skin surface lipids of acne patients and normal subjects. J Invest Dermatol. 1976 May;66(5):319-23.

Starting date: November 2013
Last updated: April 20, 2015

Page last updated: August 23, 2015

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