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Treatment and Suppression of Hairy Leukoplakia in ARC Patients With Oral Acyclovir (ACV)

Information source: NIH AIDS Clinical Trials Information Service
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Leukoplakia, Hairy; HIV Infections

Intervention: Acyclovir (Drug)

Phase: N/A

Status: Completed

Sponsored by: Glaxo Wellcome

Summary

To evaluate the efficacy of oral acyclovir for the treatment and suppression of Epstein-Barr virus (EBV) related hairy leukoplakia (HL). To determine the long-term safety of acyclovir in the AIDS-related complex (ARC) patient with HL. To monitor the progression of HIV disease in the HL patient and compare to existing historical control data.

Clinical Details

Official title: Treatment and Suppression of Hairy Leukoplakia in ARC Patients With Oral Acyclovir (ACV)

Study design: Primary Purpose: Treatment

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria Concurrent Medication: Allowed:

- Topical antifungal therapy.

Patient must have:

- Newly diagnosed clinical and histological hairy leukoplakia.

- Positive HIV antibody by licensed ELISA or Western blot.

Exclusion Criteria Co-existing Condition: Patients with AIDS or a history of intolerance or allergy to acyclovir are excluded. Concurrent Medication: Excluded within 2 weeks of study entry:

- Systemic antifungal treatment.

- Excluded within 6 weeks of study entry:

- Immunomodulators.

- Systemic antiviral treatment.

Patients with AIDS or a history of intolerance or allergy to acyclovir are excluded. Prior Medication: Excluded within 2 weeks of study entry:

- Systemic antifungal.

- Excluded within 6 weeks of study entry:

- Immunomodulators.

- Systemic antiviral treatment.

- Excluded within 8 weeks of study entry:

- Zidovudine (AZT) or other antiretroviral therapy.

Locations and Contacts

Univ of Southern California / LA County USC Med Ctr, Los Angeles, California 900331079, United States
Additional Information

Related publications:

Herbst JS, Morgan J, Raab-Traub N, Resnick L. Comparison of the efficacy of surgery and acyclovir therapy in oral hairy leukoplakia. J Am Acad Dermatol. 1989 Oct;21(4 Pt 1):753-6.


Last updated: June 23, 2005

Page last updated: August 23, 2015

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